Agarose Hydrogels Enriched by Humic Acids as a Functional Model for the Transport of Pharmaceuticals in Nature Systems

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dc.contributor.authorKlučáková, Martinacs
dc.contributor.authorZávodská, Petracs
dc.coverage.issue24cs
dc.coverage.volume29cs
dc.date.accessioned2025-06-10T11:55:58Z
dc.date.available2025-06-10T11:55:58Z
dc.date.issued2024-12-16cs
dc.description.abstractThe presence of pharmaceuticals in nature systems poses a threat to the environment, plants, animals, and, last but not least, human health. Their transport in soils, waters, and sediments plays important roles in the toxicity and bioavailability of pharmaceuticals. The mobility of pharmaceuticals can be affected by their interactions with organic matter and other soil and water constituents. In this study, a model agarose hydrogel enriched by humic acid as a representative of organic matter is used as a transport medium for pharmaceuticals. Sulphapyridine (as a representative of sulphonamide antibiotics) and diclofenac (as a representative of widely used non-steroidal anti-inflammatory drugs) were chosen for experiments in diffusion cells. Pharmaceuticals were passed through the hydrogel from the donor solution to the acceptor compartment and could interact with humic acids incorporated in the hydrogel. The lag time was prolonged if the hydrogel was enriched by humic acids from 134 to 390 s for sulphapyridine and from 323 to 606 s for diclofenac. Similarly, the incorporation of humic acids in the hydrogel resulted in a decrease in the determined diffusion coefficients. The decrease was stronger in the first stage of the experiment when diffusing particles could interact with vacant binding sites.en
dc.description.abstractByl studován transport sulfapyridinu a diklofenaku skrz aarosové hydrogely s a bez huminových kyselin. Pokud byly přítomny, intragovaly během transportu s difundujícími léčivy a oblivňovaly tak jejich mobilitu. Ke studiu byla použita metoda horizontálních difuzních cel.cs
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMOLECULES. 2024, vol. 29, issue 24, p. 1-11.en
dc.identifier.doi10.3390/molecules29245937cs
dc.identifier.issn1420-3049cs
dc.identifier.orcid0000-0003-4969-6988cs
dc.identifier.orcid0009-0000-1588-5196cs
dc.identifier.other193693cs
dc.identifier.urihttps://hdl.handle.net/11012/251597
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofMOLECULEScs
dc.relation.urihttps://www.mdpi.com/1420-3049/29/24/5937cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1420-3049/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjecthydrogelen
dc.subjecthumic aciden
dc.subjecttransporten
dc.subjectsulphapyridineen
dc.subjectdiclofenacen
dc.subjecthydrogel
dc.subjecthuminové kyseliny
dc.subjecttransport
dc.subjectsulfapyridin
dc.subjectdiklofenak
dc.titleAgarose Hydrogels Enriched by Humic Acids as a Functional Model for the Transport of Pharmaceuticals in Nature Systemsen
dc.title.alternativeAgarosové hydrogely obohacené huminovými kyselinami jako funkční model pro transport léčiv v přírodních systémechcs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-193693en
sync.item.dbtypeVAVen
sync.item.insts2025.06.10 13:55:58en
sync.item.modts2025.06.10 13:33:05en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav fyzikální a spotřební chemiecs
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