Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

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dc.contributor.authorBrázda, Václavcs
dc.contributor.authorVálková, Natáliecs
dc.contributor.authorDobrovolná, Michaelacs
dc.contributor.authorMergny, Jean-Louiscs
dc.coverage.issue3cs
dc.coverage.volume9cs
dc.date.accessioned2024-02-23T14:45:32Z
dc.date.available2024-02-23T14:45:32Z
dc.date.issued2024-01-09cs
dc.description.abstractHepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to be infectious. Its compact and variable single-stranded RNA genome consists of eight major genotypes distributed unevenly across different continents. The significance of noncanonical secondary structures such as G-quadruplexes (G4s) is increasingly recognized at the DNA and RNA levels, particularly for transcription, replication, and translation. G4s are formed from guanine-rich sequences and have been identified in the vast majority of viral, eukaryotic, and prokaryotic genomes. In this study, we analyzed the G4 propensity of HDV genomes by using G4Hunter. Unlike HBV, which has a G4 density similar to that of the human genome, HDV displays a significantly higher number of potential quadruplex-forming sequences (PQS), with a density more than four times greater than that of the human genome. This finding suggests a critical role for G4s in HDV, especially given that the PQS regions are conserved across HDV genotypes. Furthermore, the prevalence of G4-forming sequences may represent a promising target for therapeutic interventions to control HDV replication.en
dc.formattextcs
dc.format.extent4096-4101cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS OMEGA. 2024, vol. 9, issue 3, p. 4096-4101.en
dc.identifier.doi10.1021/acsomega.3c09288cs
dc.identifier.issn2470-1343cs
dc.identifier.orcid0000-0003-2837-4226cs
dc.identifier.other187730cs
dc.identifier.researcheridF-9582-2011cs
dc.identifier.urihttps://hdl.handle.net/11012/245216
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS OMEGAcs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsomega.3c09288cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2470-1343/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectG-quadruplexen
dc.subjectHDVen
dc.subjectSecondary structuresen
dc.titleAbundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-187730en
sync.item.dbtypeVAVen
sync.item.insts2024.02.23 15:45:31en
sync.item.modts2024.02.23 15:13:18en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
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