The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct

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dc.contributor.authorJanečková, Kláracs
dc.contributor.authorRoos, Christiancs
dc.contributor.authorFedrová, Pavlacs
dc.contributor.authorTom, Nikolacs
dc.contributor.authorČejková, Darinacs
dc.contributor.authorLueert, Simonecs
dc.contributor.authorKeyyu, Julius Dcs
dc.contributor.authorChuma, Idrissa S.cs
dc.contributor.authorKnauf, Saschacs
dc.contributor.authorŠmajs, Davidcs
dc.coverage.issue9cs
dc.coverage.volume17cs
dc.date.issued2023-09-13cs
dc.description.abstractBACKGROUND: Treponema pallidum subsp. pertenue (TPE) is the causative agent of human yaws. Yaws is currently reported in 13 endemic countries in Africa, southern Asia, and the Pacific region. During the mid-20th century, a first yaws eradication effort resulted in a global 95% drop in yaws prevalence. The lack of continued surveillance has led to the resurgence of yaws. The disease was believed to have no animal reservoirs, which supported the development of a currently ongoing second yaws eradication campaign. Concomitantly, genetic evidence started to show that TPE strains naturally infect nonhuman primates (NHPs) in sub-Saharan Africa. In our current study we tested hypothesis that NHP- and human-infecting TPE strains differ in the previously unknown parts of the genomes. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we determined complete (finished) genomes of ten TPE isolates that originated from NHPs and compared them to TPE whole-genome sequences from human yaws patients. We performed an in-depth analysis of TPE genomes to determine if any consistent genomic differences are present between TPE genomes of human and NHP origin. We were able to resolve previously undetermined TPE chromosomal regions (sequencing gaps) that prevented us from making a conclusion regarding the sequence identity of TPE genomes from NHPs and humans. The comparison among finished genome sequences revealed no consistent differences between human and NHP TPE genomes. CONCLUSION/SIGNIFICANCE: Our data show that NHPs are infected with strains that are not only similar to the strains infecting humans but are genomically indistinguishable from them. Although interspecies transmission in NHPs is a rare event and evidence for current spillover events is missing, the existence of the yaws bacterium in NHPs is demonstrated. While the low risk of spillover supports the current yaws treatment campaign, it is of importance to continue yaws surveillance in areas where NHPs are naturally infected with TPE even if yaws is successfully eliminated in humans.en
dc.formattextcs
dc.format.extent21cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS NEGLECT TROP D. 2023, vol. 17, issue 9, 21 p.en
dc.identifier.doi10.1371/journal.pntd.0011602cs
dc.identifier.issn1935-2735cs
dc.identifier.orcid0000-0002-6989-6330cs
dc.identifier.other184890cs
dc.identifier.scopus23099215700cs
dc.identifier.urihttp://hdl.handle.net/11012/244167
dc.language.isoencs
dc.publisherPublic Library of Sciencecs
dc.relation.ispartofPLOS NEGLECT TROP Dcs
dc.relation.urihttps://pubmed.ncbi.nlm.nih.gov/37703251/cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1935-2735/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectAnimalsen
dc.subjectBacteriaen
dc.subjectHumansen
dc.subjectPrimatesen
dc.subjectTreponemaen
dc.subjectTreponema pallidum subsp. pertenueen
dc.subjectYawsen
dc.titleThe genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distincten
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184890en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:57en
sync.item.modts2025.01.17 15:14:04en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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