Experimental methods for flow and aerosol measurements in human airways and their replicas

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dc.contributor.authorLízal, Františekcs
dc.contributor.authorJedelský, Jancs
dc.contributor.authorMorgan, Kayecs
dc.contributor.authorBauer, Katrincs
dc.contributor.authorLlop, Jordics
dc.contributor.authorCossio, Unaics
dc.contributor.authorKassinos, Stavroscs
dc.contributor.authorVerbanck, Sylviacs
dc.contributor.authorRuiz-Cabello, Jesúscs
dc.contributor.authorSantos, Arnoldocs
dc.contributor.authorKoch, Edmundcs
dc.contributor.authorSchnabel, Christiancs
dc.coverage.issueSIcs
dc.coverage.volume113cs
dc.date.accessioned2022-01-28T15:54:34Z
dc.date.available2022-01-28T15:54:34Z
dc.date.issued2018-02-15cs
dc.description.abstractRecent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.en
dc.formattextcs
dc.format.extent95-131cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018, vol. 113, issue SI, p. 95-131.en
dc.identifier.doi10.1016/j.ejps.2017.08.021cs
dc.identifier.issn0928-0987cs
dc.identifier.other143632cs
dc.identifier.urihttp://hdl.handle.net/11012/203515
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCEScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0928098717304657cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0928-0987/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectComputational fluid particle dynamicsen
dc.subjectHuman airwaysen
dc.subjectLungsen
dc.subjectExperimental methodsen
dc.subjectMedical imagingen
dc.subjectAerosol depositionen
dc.subjectVelocimetry techniquesen
dc.subjectFlow measurement techniquesen
dc.subjectGas–liquid two-phase flowen
dc.subjectCFD validationen
dc.titleExperimental methods for flow and aerosol measurements in human airways and their replicasen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionacceptedVersionen
sync.item.dbidVAV-143632en
sync.item.dbtypeVAVen
sync.item.insts2022.01.28 16:54:34en
sync.item.modts2022.01.28 16:14:13en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. EÚ-odbor termomechaniky a techniky prostředícs
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