Mechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig model

Simple item page
dc.contributor.authorFedorová, Petracs
dc.contributor.authorSrnec, Robertcs
dc.contributor.authorPěnčík, Jancs
dc.contributor.authorSchmid, Pavelcs
dc.contributor.authorAmler, Evžencs
dc.contributor.authorUrbanová, Luciecs
dc.contributor.authorNečas, Aloiscs
dc.coverage.issue1cs
dc.coverage.volume83cs
dc.date.issued2014-04-01cs
dc.description.abstractThe study deals with mechanical testing of newly developed material polyethylene terephtalate coated with polycaprolactone nanofibers in combination with biodagradable Hexalon ACL/PCL screws as a new possibility of intra-articular reinforcement of partially ruptured cranial cruciate ligament. Four groups of ex vivo models of pig stifle joints were prepared and tested: a model with intact CCL (group 1), a model with partial CCL rupture (group 2), a model with CCL rupture stabilized with 7 mm Mersilene strip (group 3), and a model with CCL rupture stabilized with 5 mm PET/PCL biomaterial strip (group 4). The models were loaded in the standing angle of 100deg and the maximum load (N) and the shift (mm) were monitored. The mean maximum peak power and the shift were 1266.0 +/- 146.9 N and 13.7 +/- 2.5 mm for group 1, and 1164.7 +/- 228.2 N and 1 6.8 +/- 3.3 mm for group 2, respectively. In all cases after reaching the maximum load, a tibial fracture occurred but never a CCL rupture. In groups 3 and 4, the initial fixation failure occurred in the mean values of 375.7 +/- 81.5 and 360.4 +/- 52.0 N, respectively, and with a bigger shift of 52.3 +/- 11.9 mm and 39.4 +/- 14.6 mm, respectively, compared to group 1. A critical point of failure was the anchoring in the bone. It can be concluded that the PET/PCL substitute in the ex vivo model has mechanically comparable properties with the clinically used Mersilene, and based on its proven ability to carry stem cells it could be appropriate for partially ruptured CCL protection.en
dc.description.abstractThe study deals with mechanical testing of newly developed material polyethylene terephtalate coated with polycaprolactone nanofibers in combination with biodagradable Hexalon ACL/PCL screws as a new possibility of intra-articular reinforcement of partially ruptured cranial cruciate ligament. Four groups of ex vivo models of pig stifle joints were prepared and tested: a model with intact CCL (group 1), a model with partial CCL rupture (group 2), a model with CCL rupture stabilized with 7 mm Mersilene strip (group 3), and a model with CCL rupture stabilized with 5 mm PET/PCL biomaterial strip (group 4). The models were loaded in the standing angle of 100deg and the maximum load (N) and the shift (mm) were monitored. The mean maximum peak power and the shift were 1266.0 +/- 146.9 N and 13.7 +/- 2.5 mm for group 1, and 1164.7 +/- 228.2 N and 1 6.8 +/- 3.3 mm for group 2, respectively. In all cases after reaching the maximum load, a tibial fracture occurred but never a CCL rupture. In groups 3 and 4, the initial fixation failure occurred in the mean values of 375.7 +/- 81.5 and 360.4 +/- 52.0 N, respectively, and with a bigger shift of 52.3 +/- 11.9 mm and 39.4 +/- 14.6 mm, respectively, compared to group 1. A critical point of failure was the anchoring in the bone. It can be concluded that the PET/PCL substitute in the ex vivo model has mechanically comparable properties with the clinically used Mersilene, and based on its proven ability to carry stem cells it could be appropriate for partially ruptured CCL protection.cs
dc.formattextcs
dc.format.extent56-60cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACTA VETERINARIA BRNO. 2014, vol. 83, issue 1, p. 56-60.en
dc.identifier.doi10.2754/avb201483010055cs
dc.identifier.issn0001-7213cs
dc.identifier.orcid0000-0002-2295-0088cs
dc.identifier.orcid0000-0001-5546-445Xcs
dc.identifier.other106893cs
dc.identifier.researcheridAAD-6995-2019cs
dc.identifier.researcheridAAX-7864-2020cs
dc.identifier.scopus51061468700cs
dc.identifier.scopus57217718154cs
dc.identifier.urihttp://hdl.handle.net/11012/102744
dc.language.isoencs
dc.publisherUniversity of Veterinary and Pharmaceutical Sciences in Brnocs
dc.relation.ispartofACTA VETERINARIA BRNOcs
dc.relation.urihttps://actavet.vfu.cz/83/1/0055/cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0001-7213/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectKnee stabilizationen
dc.subjectstifle surgeryen
dc.subjectpolycaprolactone nanofibreen
dc.subjectpolyesteren
dc.subjectsynthetic materialen
dc.subjectbiodegradable screwen
dc.subjectKnee stabilization
dc.subjectstifle surgery
dc.subjectpolycaprolactone nanofibre
dc.subjectpolyester
dc.subjectsynthetic material
dc.subjectbiodegradable screw
dc.titleMechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig modelen
dc.title.alternativeMechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig modelcs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-106893en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:44:49en
sync.item.modts2025.01.17 15:28:45en
thesis.grantorVysoké učení technické v Brně. Fakulta stavební. Ústav pozemního stavitelstvícs
thesis.grantorVysoké učení technické v Brně. Fakulta stavební. Ústav stavebního zkušebnictvícs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
avb_2014083010055.pdf
Size:
1.32 MB
Format:
Adobe Portable Document Format
Description:
avb_2014083010055.pdf
Download
Collections
Ústav pozemního stavitelství
Ústav stavebního zkušebnictví