Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of GlimepirideCaptisol Inclusion Complexes

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dc.contributor.authorPal, Arpitacs
dc.contributor.authorRoy, Sudeepcs
dc.contributor.authorKumar, Akhilcs
dc.contributor.authorMahmood, Syedcs
dc.contributor.authorKhodapanah, Nasrincs
dc.contributor.authorThomas, Sabucs
dc.contributor.authorAgatemor, Christiancs
dc.contributor.authorGhosal, Kajalcs
dc.coverage.issue32cs
dc.coverage.volume5cs
dc.date.issued2020-08-01cs
dc.description.abstractThis present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepirideCaptisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepirideCaptisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepirideCaptisol complex was higher in distilled water of pH 6.0 than in phosphate buffer of pH 7.2.en
dc.formattextcs
dc.format.extent19968-19977cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS OMEGA. 2020, vol. 5, issue 32, p. 19968-19977.en
dc.identifier.doi10.1021/acsomega.0c01228cs
dc.identifier.issn2470-1343cs
dc.identifier.orcid0000-0002-7825-0152cs
dc.identifier.other165567cs
dc.identifier.scopus000000278250152cs
dc.identifier.urihttp://hdl.handle.net/11012/196516
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS OMEGAcs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsomega.0c01228cs
dc.rights(C) American Chemical Societycs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2470-1343/cs
dc.subjectGlimepirideen
dc.subjectCaptisolen
dc.subjectmolecular dockingen
dc.subjectmolecular simulationen
dc.titlePhysicochemical Characterization, Molecular Docking, and In Vitro Dissolution of GlimepirideCaptisol Inclusion Complexesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-165567en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:46en
sync.item.modts2025.01.17 16:34:38en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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