Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering

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dc.contributor.authorKhunová, Vieracs
dc.contributor.authorKováčová, Mariacs
dc.contributor.authorOlejníková, Petracs
dc.contributor.authorOndreáš, Františekcs
dc.contributor.authorŠpitálsky, Zdenkocs
dc.contributor.authorGhosal, Kajalcs
dc.contributor.authorBerkeš, Dušancs
dc.coverage.issue4cs
dc.coverage.volume14cs
dc.date.issued2022-02-01cs
dc.description.abstractDue to its slow degradation rate, polycaprolactone (PCL) is frequently used in biomedical applications. This study deals with the development of antibacterial nanofibers based on PCL and halloysite nanotubes (HNTs). Thanks to a combination with HNTs, the prepared nanofibers can be used as low-cost nanocontainers for the encapsulation of a wide variety of substances, including drugs, enzymes, and DNA. In our work, HNTs were used as a nanocarrier for erythromycin (ERY) as a model antibacterial active compound with a wide range of antibacterial activity. Nanofibers based on PCL and HNT/ERY were prepared by electrospinning. The antibacterial activity was evaluated as a sterile zone of inhibition around the PCL nanofibers containing 7.0 wt.% HNT/ERY. The morphology was observed with SEM and TEM. The efficiency of HNT/ERY loading was evaluated with thermogravimetric analysis. It was found that the nanofibers exhibited outstanding antibacterial properties and inhibited both Gram- (Escherichia coli) and Gram+ (Staphylococcus aureus) bacteria. Moreover, a significant enhancement of mechanical properties was achieved. The potential uses of antibacterial, environmentally friendly, nontoxic, biodegradable PCL/HNT/ERY nanofiber materials are mainly in tissue engineering, wound healing, the prevention of bacterial infections, and other biomedical applications.en
dc.formattextcs
dc.format.extent746-cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPolymers. 2022, vol. 14, issue 4, p. 746-.en
dc.identifier.doi10.3390/polym14040746cs
dc.identifier.issn2073-4360cs
dc.identifier.orcid0000-0003-3845-1766cs
dc.identifier.other179280cs
dc.identifier.researcheridAAC-2596-2019cs
dc.identifier.scopus55990617200cs
dc.identifier.urihttp://hdl.handle.net/11012/209170
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofPolymerscs
dc.relation.urihttps://www.mdpi.com/2073-4360/14/4/746cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2073-4360/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectbiocompatibleen
dc.subjectantibacterialen
dc.subjecthalloysiteen
dc.subjecterythromycinen
dc.subjectpolycaprolactoneen
dc.subjectnanofibersen
dc.subjectelectrospinningen
dc.subjecttissue engineeringen
dc.titleAntibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineeringen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-179280en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:51:23en
sync.item.modts2025.01.17 16:47:51en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé polymerní materiály a kompozitcs
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