Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

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dc.contributor.authorDražanová, Evacs
dc.contributor.authorRudá-Kučerová, Janacs
dc.contributor.authorKrátká, Luciecs
dc.contributor.authorStark, Tiborcs
dc.contributor.authorKuchař, Martincs
dc.contributor.authorMaryška, Michalcs
dc.contributor.authorDrago, Filippocs
dc.contributor.authorStarčuk, Zenoncs
dc.contributor.authorMicale, Vincenzocs
dc.coverage.issue1cs
dc.coverage.volume9cs
dc.date.issued2019-04-15cs
dc.description.abstractClinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2019, vol. 9, issue 1, p. 1-10.en
dc.identifier.doi10.1038/s41598-019-42532-zcs
dc.identifier.issn2045-2322cs
dc.identifier.other169903cs
dc.identifier.urihttp://hdl.handle.net/11012/202970
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttps://www.nature.com/articles/s41598-019-42532-zcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmethylazoxymethanol acetateen
dc.subjectanimal-modelsen
dc.subjectbrain structureen
dc.subjectcannabis useen
dc.subjectschizophreniaen
dc.subjectflowen
dc.subjectmetaanalysisen
dc.subjectsymptomsen
dc.subjectdelta(9)-tetrahydrocannabinolen
dc.subjectdelta-9-tetrahydrocannabinolen
dc.titleDifferent effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in ratsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-169903en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:50en
sync.item.modts2025.01.17 15:30:43en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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