Comparative analysis of retinal photoplethysmographic spatial maps and thickness of retinal nerve fiber layer

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dc.contributor.authorOdstrčilík, Jancs
dc.contributor.authorKolář, Radimcs
dc.contributor.authorHorn, Folkertcs
dc.contributor.authorTornow, Ralf-Petercs
dc.coverage.issue5cs
dc.coverage.volume18cs
dc.date.issued2023-05-05cs
dc.description.abstractThe paper presents a comparative study of the pulsatile attenuation amplitude (PAA) within the optic nerve head (ONH) at four different areas calculated from retinal video sequences and its relevance to the retinal nerve fiber layer thickness (RNFL) changes in normal subjects and patients with different stages of glaucoma. The proposed methodology utilizes processing of retinal video sequences acquired by a novel video ophthalmoscope. The PAA parameter measures the amplitude of heartbeat-modulated light attenuation in retinal tissue. Correlation analysis between PAA and RNFL is performed in vessel-free locations of the peripapillary region with the proposed evaluating patterns: 360 & DEG; circular area, temporal semi-circle, nasal semi-circle. For comparison, the full ONH area is also included. Various positions and sizes of evaluating patterns in peripapillary region were tested which resulted in different outputs of correlation analysis. The results show significant correlation between PAA and RNFL thickness calculated in proposed areas. The highest correlation coefficient R-temp = 0.557 (p<0.001) reflects the highest PAA-RNFL correspondence in the temporal semi-circular area, compared to the lowest value in the nasal semi-circular area (R-nasal = 0.332, p<0.001). Furthermore, the results indicate the most relevant approach to calculate PAA from the acquired video sequences is using a thin annulus near the ONH center. Finally, the paper shows the proposed photoplethysmographic principle based on innovative video ophthalmoscope can be used to analyze changes in retinal perfusion in peripapillary area and can be potentially used to assess progression of the RNFL deterioration.en
dc.formattextcs
dc.format.extent1-15cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS ONE. 2023, vol. 18, issue 5, p. 1-15.en
dc.identifier.doi10.1371/journal.pone.0284743cs
dc.identifier.issn1932-6203cs
dc.identifier.orcid0000-0001-7053-6183cs
dc.identifier.orcid0000-0002-0469-6397cs
dc.identifier.other184176cs
dc.identifier.researcheridA-2237-2016cs
dc.identifier.researcheridC-8547-2014cs
dc.identifier.scopus35753651000cs
dc.identifier.urihttp://hdl.handle.net/11012/213628
dc.language.isoencs
dc.publisherPUBLIC LIBRARY SCIENCEcs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0284743cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectGlaucoma; Humans; Nerve Fibers; Optic Disk; Retinal Ganglion Cells; Tomographyen
dc.subjectOptical Coherenceen
dc.subjectglaucomaen
dc.subjecthumanen
dc.subjectnerve fiberen
dc.subjectoptical coherence tomographyen
dc.subjectproceduresen
dc.subjectretina ganglion cellen
dc.titleComparative analysis of retinal photoplethysmographic spatial maps and thickness of retinal nerve fiber layeren
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184176en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:57en
sync.item.modts2025.01.18 00:31:58en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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