Simulation of Airway Deposition of an Aerosol Drug in COPD Patients

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dc.contributor.authorFarkas, Árpádcs
dc.contributor.authorLízal, Františekcs
dc.contributor.authorJedelský, Jancs
dc.contributor.authorElcner, Jakubcs
dc.contributor.authorHorváth, Alpárcs
dc.contributor.authorJícha, Miroslavcs
dc.coverage.issue4cs
dc.coverage.volume11cs
dc.date.issued2019-04-01cs
dc.description.abstractMedical aerosols are key elements of current chronic obstructive pulmonary disease (COPD) therapy. Therapeutic effects are conditioned by the delivery of the right amount of medication to the right place within the airways, that is, to the drug receptors. Deposition of the inhaled drugs is sensitive to the breathing pattern of the patients which is also connected with the patient's disease severity. The objective of this work was to measure the realistic inhalation profiles of mild, moderate, and severe COPD patients, simulate the deposition patterns of Symbicort((R)) Turbuhaler((R)) dry powder drug and compare them to similar patterns of healthy control subjects. For this purpose, a stochastic airway deposition model has been applied. Our results revealed that the amount of drug depositing within the lungs correlated with the degree of disease severity. While drug deposition fraction in the lungs of mild COPD patients compared with that of healthy subjects (28% versus 31%), lung deposition fraction characteristic of severe COPD patients was lower by a factor of almost two (about 17%). Deposition fraction of moderate COPD patients was in-between (23%). This implies that for the same inhaler dosage severe COPD patients receive a significantly lower lung dose, although, they would need more.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPharmaceutics. 2019, vol. 11, issue 4, p. 1-10.en
dc.identifier.doi10.3390/pharmaceutics11040153cs
dc.identifier.issn1999-4923cs
dc.identifier.orcid0000-0002-0389-608Xcs
dc.identifier.orcid0000-0002-1268-8434cs
dc.identifier.orcid0000-0001-9287-4458cs
dc.identifier.orcid0000-0002-1409-5165cs
dc.identifier.other156512cs
dc.identifier.researcheridD-4363-2018cs
dc.identifier.researcheridA-9224-2013cs
dc.identifier.researcheridI-3748-2018cs
dc.identifier.researcheridCVT-7747-2022cs
dc.identifier.scopus54966786300cs
dc.identifier.scopus23090535800cs
dc.identifier.scopus55090074500cs
dc.identifier.scopus6602494673cs
dc.identifier.urihttp://hdl.handle.net/11012/156796
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofPharmaceuticscs
dc.relation.urihttps://www.mdpi.com/1999-4923/11/4/153cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1999-4923/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectaerosol drug depositionen
dc.subjectinhalation profile measurementsen
dc.subjectdry powder inhalersen
dc.titleSimulation of Airway Deposition of an Aerosol Drug in COPD Patientsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-156512en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:47:10en
sync.item.modts2025.01.17 15:21:34en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. EÚ-odbor termomechaniky a techniky prostředícs
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