Digital Biomarkers for Assessing Respiratory Disorders in Parkinson’s Disease

Abstract

Respiratory disorders are a significant part of hypokineticdysarthria (HD) that affects patients with Parkinson’sdisease (PD). Still, their potential role in the objective assessmentof HD has not yet been fully explored, which is the primary goalof this study. Several respiratory features were designed andextracted from acoustic signals recorded during text reading.Based on these features, the XGBoost model was able to predictclinical test scores of phonorespiration with an estimated errorrate of 12.54%. Statistical analysis revealed that measuring respirationrate and quantifying signal fluctuations during inspirationhave great potential in the objective assessment of respiratorydisorders in patients with PD.