On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems
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Date
2023-02-07
Authors
Slaninová, Eva
Obruča, Stanislav
Kocherbitov, Vitaly
Sedláček, Petr
0000-0002-1808-8632Advisor
Referee
Mark
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Biophysical Society
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Abstract
The comprehensive study of the phase behavior of sodium 3-hydroxybutyrate (Na3HB) in aqueous mixtures has shed new light on the recently revealed bioprotective role of this compound in poly(3-hydroxybutyrate)-accumulating microorganisms. The outstandingly hydrophilic nature of 3HB is shown, which is comparable with, but in some perspectives (solubility, water activity decreased in solution) even better than some well-recognized compatible solutes such as trehalose. This is of crucial importance also from the view of its potential application in the technological fields in which stabilization of biological molecules is required (e.g., cryopreservation, food preservation, cosmetics). The study also revealed that 3HB can form, depending on the conditions, at least two different crystalline forms: anhydrous crystal and crystalline dihydrates.
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Citation
BIOPHYSICAL JOURNAL. 2023, vol. 122, issue 3, p. 460-469.
https://www.sciencedirect.com/science/article/pii/S0006349523000048
https://www.sciencedirect.com/science/article/pii/S0006349523000048
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Peer-reviewed
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en
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/