Probing natural molecules with PPAR-γ to reveal potent agonist against Cancer

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but.event.date23.04.2024cs
but.event.titleSTUDENT EEICT 2024cs
dc.contributor.authorŠpaková, Adriána
dc.contributor.authorPankaj, Vaishali
dc.contributor.authorBhogal, Inderjeet
dc.contributor.authorRoy, Sudeep
dc.date.accessioned2024-07-09T07:47:47Z
dc.date.available2024-07-09T07:47:47Z
dc.date.issued2024cs
dc.description.abstractThe work focuses on searching for a molecule with potential agonistic properties against cancer. Molecules from six databases were screened and docked to peroxisome proliferatoractivated receptor gamma (PPAR-𝛾) by using computer aided drug design approach. Hits underwent further exploration, including dynamic simulation and safety verification. Piperlongumine - naturally occurring small molecule, derived from long pepper (Piper longum) showed after comparison with standards Troglitazone and Rosiglitazone promising results.en
dc.formattextcs
dc.format.extent65-69cs
dc.format.mimetypeapplication/pdfen
dc.identifier.citationProceedings II of the 30st Conference STUDENT EEICT 2024: Selected papers. s. 65-69. ISBN 978-80-214-6230-4cs
dc.identifier.doi10.13164/eeict.2024.65
dc.identifier.isbn978-80-214-6230-4
dc.identifier.issn2788-1334
dc.identifier.urihttps://hdl.handle.net/11012/249282
dc.language.isoencs
dc.publisherVysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.relation.ispartofProceedings II of the 30st Conference STUDENT EEICT 2024: Selected papersen
dc.relation.urihttps://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2024_sbornik_2.pdfcs
dc.rights© Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.rights.accessopenAccessen
dc.subjectCanceren
dc.subjectPPAR-𝛾en
dc.subjecttargeten
dc.subjectnatural moleculesen
dc.subjectliganden
dc.subjectvirtual screeningen
dc.subjectmolecular dockingen
dc.subjectdynamic simulationen
dc.subjectADMETen
dc.titleProbing natural molecules with PPAR-γ to reveal potent agonist against Canceren
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
eprints.affiliatedInstitution.departmentFakulta elektrotechniky a komunikačních technologiícs
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