Influence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airways

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dc.contributor.authorMisik, Ondrejcs
dc.contributor.authorPrinz, Frantisekcs
dc.contributor.authorElcner, Jakubcs
dc.contributor.authorCabalka, Matoušcs
dc.contributor.authorBelka, Miloslavcs
dc.contributor.authorLízal, Františekcs
dc.coverage.issue188cs
dc.date.accessioned2025-10-23T14:05:18Z
dc.date.available2025-10-23T14:05:18Z
dc.date.issued2025-06-13cs
dc.description.abstractBreathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine. This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 mu m in diameter, based on the recorded boundary conditions. The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.en
dc.description.abstractBreathing flow rate profiles are crucial for predicting aerosol drug delivery. While aerosol particle characteristics are determined by the inhalation device, breathing profiles are patient-specific, making them an essential topic for personalized medicine. This study investigates the influence of nebulizer pressure drop on breathing profiles and subsequent aerosol deposition within human airways. Ten male subjects performed spontaneous, and slow and deep breathing manoeuvres through three different nebulizers (one jet and two mesh nebulizers). Breathing profiles were recorded, and the impact of nebulizer pressure drop on flow rate profiles was analyzed. Computational modelling of airway aerosol deposition was performed for particles ranging from 1 to 10 mu m in diameter, based on the recorded boundary conditions. The jet nebulizer exhibited the most significant flow rate decrease due to its high pressure drop, increasing particle deposition in the lower airways. These findings are important for personalized modelling and the application of a digital twin approach in treatment design, leading to more effective and targeted drug delivery.en
dc.formattextcs
dc.format.extent18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJOURNAL OF AEROSOL SCIENCE. 2025, issue 188, 18 p.en
dc.identifier.doi10.1016/j.jaerosci.2025.106620cs
dc.identifier.issn0021-8502cs
dc.identifier.orcid0000-0002-5394-3817cs
dc.identifier.orcid0000-0002-0389-608Xcs
dc.identifier.other199208cs
dc.identifier.researcheridKAO-8851-2024cs
dc.identifier.researcheridHPH-0627-2023cs
dc.identifier.researcheridCPP-3120-2022cs
dc.identifier.researcheridAFF-1248-2022cs
dc.identifier.researcheridDUW-1826-2022cs
dc.identifier.researcheridD-4363-2018cs
dc.identifier.scopus57442532900cs
dc.identifier.scopus54966786300cs
dc.identifier.urihttps://hdl.handle.net/11012/255597
dc.language.isoencs
dc.relation.ispartofJOURNAL OF AEROSOL SCIENCEcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0021850225000977?pes=vor&utm_source=clarivate&getft_integrator=clarivatecs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0021-8502/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectNebulizeren
dc.subjectAerosolen
dc.subjectBreathing profileen
dc.subjectInhalationen
dc.subjectAirwaysen
dc.subjectDepositionen
dc.subjectNebulizer
dc.subjectAerosol
dc.subjectBreathing profile
dc.subjectInhalation
dc.subjectAirways
dc.subjectDeposition
dc.titleInfluence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airwaysen
dc.title.alternativeInfluence of nebulizer pressure drop on breathing profiles and aerosol deposition in human airwaysen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-199208en
sync.item.dbtypeVAVen
sync.item.insts2025.10.23 16:05:17en
sync.item.modts2025.10.23 15:32:15en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. EÚ-odbor termomechaniky a techniky prostředícs
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