T1 mapping of myocardium in rats using self-gated golden-angle acquisition
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Date
2023-10-09
Authors
Vitouš, Jiří
Jiřík, Radovan
Stračina, Tibor
Hendrych, Michal
Nádeníček, Jaroslav
Macíček, Ondřej
Tian, Ye
Krátká, Lucie
Dražanová, Eva
Nováková, Marie
0000-0002-9183-8794Advisor
Referee
Mark
Journal Title
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Volume Title
Publisher
John Wiley and Sons
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Abstract
PurposeThe aim of this study is to design a method of myocardial T1 quantification in small laboratory animals and to investigate the effects of spatiotemporal regularization and the needed acquisition duration.MethodsWe propose a compressed-sensing approach to T1 quantification based on self-gated inversion-recovery radial two/three-dimensional (2D/3D) golden-angle stack-of-stars acquisition with image reconstruction performed using total-variation spatiotemporal regularization. The method was tested on a phantom and on a healthy rat, as well as on rats in a small myocardium-remodeling study.ResultsThe results showed a good match of the T1 estimates with the results obtained using the ground-truth method on a phantom and with the literature values for rats myocardium. The proposed 2D and 3D methods showed significant differences between normal and remodeling myocardium groups for acquisition lengths down to approximately 5 and 15 min, respectively.ConclusionsA new 2D and 3D method for quantification of myocardial T1 in rats was proposed. We have shown the capability of both techniques to distinguish between normal and remodeling myocardial tissue. We have shown the effects of image-reconstruction regularization weights and acquisition length on the T1 estimates.
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Citation
MAGNETIC RESONANCE IN MEDICINE. 2023, vol. 91, issue 1, p. 368-380.
https://onlinelibrary.wiley.com/doi/10.1002/mrm.29846
https://onlinelibrary.wiley.com/doi/10.1002/mrm.29846
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Peer-reviewed
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Published version
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en
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/