Controlling the internal microstructure and properties of physically cross-linked PVA hydrogels by the rate of freezing
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Date
2021-01-01
Authors
Trudičová, Monika
Zahrádka, Jan
Sedláček, Petr
Pekař, Miloslav
0000-0001-7268-5641Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
TANGER Ltd.
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Abstract
PVA hydrogels can be formed via physical crosslinking (e.g. by cyclic freezing/thawing of aqueous polyvinyl alcohol solutions) or with a chemical cross-linker. Physical crosslinking is more useful for biomedical applications since it contains no harmful cross-linker residues. This work, therefore, focused on studying properties of physically crosslinked hydrogels with different concentrations of polyvinyl alcohol (2.5 to 15 wt%) prepared via cyclic freezing/thawing under different cryogenic conditions: in the liquid nitrogen (-196 degrees C), in two different laboratory freezers (-80 degrees C and -18 degrees C) and the ice bath. Furthermore, the effects of the addition of several cryoprotectants were evaluated. The optical and mechanical properties of the prepared samples were studied, and the microstructure of the hydrogels was observed by scanning electron microscopy after freeze-drying.
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Citation
Proceedings 12th International Conference on Nanomaterials - Research & Application. 2021, p. 547-552.
https://www.confer.cz/nanocon/2020/3769-controlling-the-internal-microstructure-and-properties-of-physically-cross-linked-pva-hydrogels-by-the-rate-of-freezing
https://www.confer.cz/nanocon/2020/3769-controlling-the-internal-microstructure-and-properties-of-physically-cross-linked-pva-hydrogels-by-the-rate-of-freezing
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Peer-reviewed
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Published version
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en