Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution

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dc.contributor.authorMaděránková, Denisacs
dc.contributor.authorMikalová, Lenkacs
dc.contributor.authorStrouhal, Michalcs
dc.contributor.authorVadják, Šimoncs
dc.contributor.authorKuklová, Ivanacs
dc.contributor.authorPospíšilová, Petracs
dc.contributor.authorKrbková, Lenkacs
dc.contributor.authorCicková, Pavlínacs
dc.contributor.authorProvazník, Valentýnacs
dc.contributor.authorŠmajs, Davidcs
dc.coverage.issue6cs
dc.coverage.volume13cs
dc.date.issued2019-06-19cs
dc.description.abstractIn the genus Treponema there are several human and animal pathogens that include the causative agent of syphilis (Treponema pallidum ssp. pallidum; TPA), the causative agent of yaws (T. p. ssp. pertenue; TPE), and the causative agent of endemic syphilis (T. p. ssp. endemicum; TEN). T. paraluisleporidarum causes venereal spirochetosis in rabbits. We used whole genome sequences of 11 treponemal strains together with additional 62 draft genomic data to identify genes evolving under positive selection. The identified genes evolving under positive selection partly overlapped with the genes previously reported as recombinant and were found to be different in treponemal subspecies. Since both genetic recombination and positive selection could allow a survival of pathogenic bacteria despite the human immune response, identification of such genes could predict the major antigens recognized by the human immune system and also identify the most suitable components for development of an anti-treponemal vaccine.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS NEGLECT TROP D. 2019, vol. 13, issue 6, p. 1-18.en
dc.identifier.doi10.1371/journal.pntd.0007463cs
dc.identifier.issn1935-2727cs
dc.identifier.orcid0000-0002-7309-7291cs
dc.identifier.orcid0000-0003-1341-7975cs
dc.identifier.orcid0000-0002-3422-7938cs
dc.identifier.other159054cs
dc.identifier.researcheridF-4121-2012cs
dc.identifier.scopus6701729526cs
dc.identifier.urihttp://hdl.handle.net/11012/193229
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS NEGLECT TROP Dcs
dc.relation.urihttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007463cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1935-2727/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectTreponemaen
dc.subjectsyphilisen
dc.subjectpositive selectionen
dc.titleIdentification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolutionen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-159054en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:43en
sync.item.modts2025.01.17 18:32:33en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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