Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

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but.event.date25.04.2023cs
but.event.titleSTUDENT EEICT 2023cs
dc.contributor.authorHývlová, Denisa
dc.contributor.authorVitouš, Jiří
dc.contributor.authorJiřík, Radovan
dc.date.accessioned2023-07-17T05:57:34Z
dc.date.available2023-07-17T05:57:34Z
dc.date.issued2023cs
dc.description.abstractThis paper focuses on quantification of blood-brainbarrier(BBB) opening induced by focused ultrasound. Dynamiccontrast-enhanced MRI (DCE-MRI) with two different pharmacokineticmodels, 2CX and ETK, is used to evaluate BBB opening.The ETK model is commonly used in BBB-opening studies. Wepropose use of a more advanced model, 2CX, that provides moreaccurate estimation of the BBB permeability. The accuracy of themodels is compared using simulated and real data. The resultsdemonstrate similar performance of the 2CX and ETK models inthe brain region with a highly permeable BBB, but the ETK hasproven unable to correctly detect low level of permeabilization.Thus, the 2CX model is more suitable for the studies of BBBpermeabilitydynamics.en
dc.formattextcs
dc.format.extent133-136cs
dc.format.mimetypeapplication/pdfen
dc.identifier.citationProceedings II of the 29st Conference STUDENT EEICT 2023: Selected papers. s. 133-136. ISBN 978-80-214-6154-3cs
dc.identifier.doi10.13164/eeict.2023.133
dc.identifier.isbn978-80-214-6154-3
dc.identifier.issn2788-1334
dc.identifier.urihttp://hdl.handle.net/11012/210674
dc.language.isoencs
dc.publisherVysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.relation.ispartofProceedings II of the 29st Conference STUDENT EEICT 2023: Selected papersen
dc.relation.urihttps://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdfcs
dc.rights© Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.rights.accessopenAccessen
dc.subjectDCE-MRIen
dc.subjectperfusion analysisen
dc.subjectsimulationen
dc.subjectfocusedultrasounden
dc.subjectBBB openingen
dc.titleComparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasounden
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
eprints.affiliatedInstitution.departmentFakulta elektrotechniky a komunikačních technologiícs
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