Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting

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dc.contributor.authorBiswas, Avirupcs
dc.contributor.authorMondal, Sanchareecs
dc.contributor.authorKumar Das, Sanjoycs
dc.contributor.authorBose, Anindyacs
dc.contributor.authorThomas, Sabucs
dc.contributor.authorGhosal, Kajalcs
dc.contributor.authorRoy, Sudeepcs
dc.contributor.authorProvazník, Valentýnacs
dc.coverage.issue43cs
dc.coverage.volume6cs
dc.date.issued2021-10-25cs
dc.description.abstractInterpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.en
dc.formattextcs
dc.format.extent28699-28709cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS OMEGA. 2021, vol. 6, issue 43, p. 28699-28709.en
dc.identifier.doi10.1021/acsomega.1c03363cs
dc.identifier.issn2470-1343cs
dc.identifier.orcid0000-0002-7825-0152cs
dc.identifier.orcid0000-0002-3422-7938cs
dc.identifier.other173140cs
dc.identifier.researcheridF-4121-2012cs
dc.identifier.scopus000000278250152cs
dc.identifier.scopus6701729526cs
dc.identifier.urihttp://hdl.handle.net/11012/203079
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS OMEGAcs
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2470-1343/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectNatural Productsen
dc.subjectInterpenetrating polymer networken
dc.subjectFourier transform infrared spectroscopy (FTIR)en
dc.subjectdifferential scanning calorimetry (DSC).en
dc.titleDevelopment and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targetingen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-173140en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:52en
sync.item.modts2025.01.17 19:35:50en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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