Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

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dc.contributor.authorVaverka, Jiřícs
dc.contributor.authorBurša, Jiřícs
dc.contributor.authorŠumbera, Josefcs
dc.contributor.authorPásek, Michalcs
dc.coverage.issue2018cs
dc.coverage.volume2018cs
dc.date.issued2018-05-10cs
dc.description.abstractRecent studies have shown that left ventricle (LV) exhibits considerable transmural differences in active mechanical properties induced by transmural differences in electrical activity, excitation-contraction coupling, and contractile properties of individual myocytes. It was shown that the time between electrical and mechanical activation of myocytes (electromechanical delay: EMD) decreases from subendocardium to subepicardium and, on the contrary, the myocyte shortening velocity (MSV) increases in the same direction. To investigate the physiological importance of this inhomogeneity, we developed a new finite element model of LV incorporating the observed transmural gradients in EMD and MSV. Comparative simulations with the model showed that when EMD or MSV or both were set constant across the LV wall, the LV contractility during isovolumic contraction (IVC) decreased significantly ((/)max was reduced by 2 to 38% and IVC was prolonged by 18 to 73%). This was accompanied by an increase of transmural differences in wall stress.These results suggest that the transmural differences in EMD and MSV play an important role in physiological contractility of LV by synchronising the contraction of individual layers of ventricular wall during the systole. Reduction or enhancement of these differences may therefore impair the function of LV and contribute to heart failure.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBioMed Research International. 2018, vol. 2018, issue 2018, p. 1-10.en
dc.identifier.doi10.1155/2018/4798512cs
dc.identifier.issn2314-6141cs
dc.identifier.orcid0000-0001-7044-1774cs
dc.identifier.orcid0000-0002-2960-185Xcs
dc.identifier.other147339cs
dc.identifier.scopus6602676789cs
dc.identifier.urihttp://hdl.handle.net/11012/72424
dc.language.isoencs
dc.publisherHindawics
dc.relation.ispartofBioMed Research Internationalcs
dc.relation.urihttp://dx.doi.org/10.1155/2018/4798512cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2314-6141/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectleft ventricleen
dc.subjectisovolumic contractionen
dc.subjecttransmural heterogeneityen
dc.subjectfinite element modelen
dc.titleEffect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Studyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-147339en
sync.item.dbtypeVAVen
sync.item.insts2025.02.06 10:53:54en
sync.item.modts2025.02.05 10:32:06en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav mechaniky těles, mechatroniky a biomechanikycs
thesis.grantorVysoké učení technické v Brně. . Ústav termomechaniky AV ČRcs
thesis.grantorVysoké učení technické v Brně. . Lékařská fakultacs
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