High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs

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dc.contributor.authorKnauf, Saschacs
dc.contributor.authorHisgen, Lindacs
dc.contributor.authorAgren, Erik O.cs
dc.contributor.authorBarlow, Alexander M.cs
dc.contributor.authorFaehndrich, Marcuscs
dc.contributor.authorVoigt, Ulrichcs
dc.contributor.authorFischer, Luisacs
dc.contributor.authorGrillová, Lindacs
dc.contributor.authorHallmaier-Wacker, Luisa K.cs
dc.contributor.authorKik, Marja J. L.cs
dc.contributor.authorKlink, Jana C.cs
dc.contributor.authorKřenová, Jitkacs
dc.contributor.authorLavazza, Antoniocs
dc.contributor.authorLueert, Simonecs
dc.contributor.authorNováková, Markétacs
dc.contributor.authorČejková, Darinacs
dc.contributor.authorPacioni, Carlocs
dc.contributor.authorTrogu, Tizianacs
dc.contributor.authorŠmajs, Davidcs
dc.contributor.authorRoos, Christiancs
dc.coverage.issue1cs
dc.coverage.volume12cs
dc.date.accessioned2024-02-22T10:45:21Z
dc.date.available2024-02-22T10:45:21Z
dc.date.issued2023-11-26cs
dc.description.abstractThe bacterium Treponema paraluisleporidarum causes syphilis in lagomorphs. In a set of 1,095 samples from four species—European brown hare, mountain hare, Corsican hare, and European rabbit—we tested for infection and genotyped the strains that infect wild lagomorphs. Samples originate from Sweden, the Netherlands, the United Kingdom, Germany, the Czech Republic, and Italy. The phylogenetic analyses of two informative gene targets (tp0488 and tp0548) showed high genetic diversity among the lagomorph-infecting treponemes. More specifically, we found a high number of nucleotide variants and various short repeat units in the tp0548 locus that have not been described for human syphilis and primate yaws causing Treponema pallidum. While the functional aspect of these short repeat units remains subject to ongoing investigations, it likely enables the pathogen to better survive in its lagomorph host. Our data did not support any geographic clustering, which is equally reflected in the host population genetics as shown by mitochondrial genome data corresponding to the sampled lagomorph populations. This is unexpected and in contrast with what has been shown for nonhuman primate infection with T. pallidum. In the future, the combination of multi-locus sequence typing and whole genome data from modern and ancient samples from a wide geographic range and multiple lagomorph species will contribute to a better understanding of the epidemiology and evolutionary path of lagomorph-infecting treponemes. In conclusion, our current study demonstrates widespread infection and a high genetic variation of the syphilis-causing pathogen in a higher number of positively PCR-tested European lagomorphs (n = 302/1,095).en
dc.formattextcs
dc.format.extent15cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMicrobiology spectrum. 2023, vol. 12, issue 1, 15 p.en
dc.identifier.doi10.1128/spectrum.01774-23cs
dc.identifier.issn2165-0497cs
dc.identifier.orcid0000-0002-6989-6330cs
dc.identifier.other185425cs
dc.identifier.scopus23099215700cs
dc.identifier.urihttps://hdl.handle.net/11012/245169
dc.language.isoencs
dc.publisherAmerican Society for Microbiologycs
dc.relation.ispartofMicrobiology spectrumcs
dc.relation.urihttps://journals.asm.org/journal/spectrumcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2165-0497/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectspirochetesen
dc.subjectEuropean brown hareen
dc.subjectLepusen
dc.subjectrabbiten
dc.subjectOryctolagusen
dc.subjectsyphilisen
dc.subjectTreponema pallidumen
dc.subjectone healthen
dc.titleHigh prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-185425en
sync.item.dbtypeVAVen
sync.item.insts2024.02.22 11:45:21en
sync.item.modts2024.02.22 11:13:28en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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