Chronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques - spectroscopy and perfusion

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dc.contributor.authorHaraštová-Pavlova, Ivetacs
dc.contributor.authorDražanová, Evacs
dc.contributor.authorKrátká, Luciecs
dc.contributor.authorAmchová, Petracs
dc.contributor.authorHricková, Máriacs
dc.contributor.authorMacíček, Ondřejcs
dc.contributor.authorVitouš, Jiřícs
dc.contributor.authorJiřík, Radovancs
dc.contributor.authorRuda, Janacs
dc.coverage.issue1cs
dc.coverage.volume181cs
dc.date.accessioned2025-06-10T11:55:59Z
dc.date.available2025-06-10T11:55:59Z
dc.date.issued2024-12-12cs
dc.description.abstractBackground: Major depressive disorder (MDD) is a mental illness with a high worldwide prevalence and suboptimal pharmacological treatment, which necessitates the development of novel, more efficacious MDD medication. Nuclear magnetic resonance (NMR) can non-invasively provide insight into the neurochemical state of the brain using proton magnetic resonance spectroscopy (1H MRS), and an assessment of regional cerebral blood flow (rCBF) by perfusion imaging. These methods may provide valuable in vivo markers of the pathological processes underlying MDD. Methods: This study examined the effects of the chronic antidepressant medication, citalopram, in a well-validated MDD model induced by bilateral olfactory bulbectomy (OB) in rats. 1H MRS was utilized to assess key metabolite ratios in the dorsal hippocampus and sensorimotor cortex bilaterally, and arterial spin labelling was employed to estimate rCBF in several additional brain regions. Results: The 1H MRS data results suggest lower hippocampal Cho/tCr and lower cortical NAA/tCr levels as a characteristic of the OB phenotype. Spectroscopy revealed lower hippocampal Tau/tCr in citalopram-treated rats, indicating a potentially deleterious effect of the drug. However, the significant OB model–citalopram treatment interaction was observed using 1H MRS in hippocampal mI/tCr, Glx/tCr and Gln/tCr, indicating differential treatment effects in the OB and control groups. The perfusion data revealed higher rCBF in the whole brain, hippocampus and thalamus in the OB rats, while citalopram appeared to normalise it without affecting the control group. Conclusion: Collectively, 1H MRS and rCBF approaches demonstrated their capacity to capture an OB-induced phenotype and chronic antidepressant treatment effect in multiple brain regions.en
dc.formattextcs
dc.format.extent1-13cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBIOMEDICINE & PHARMACOTHERAPY. 2024, vol. 181, issue 1, p. 1-13.en
dc.identifier.doi10.1016/j.biopha.2024.117656cs
dc.identifier.issn0753-3322cs
dc.identifier.orcid0000-0002-9183-8794cs
dc.identifier.orcid0000-0003-2555-9428cs
dc.identifier.other197783cs
dc.identifier.researcheridF-6226-2012cs
dc.identifier.scopus6507144159cs
dc.identifier.urihttps://hdl.handle.net/11012/251598
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofBIOMEDICINE & PHARMACOTHERAPYcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0753332224015427cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0753-3322/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectBrain metabolitesen
dc.subjectCerebral perfusionen
dc.subjectCitalopramen
dc.subjectDepressionen
dc.subjectOlfactory bulbectomyen
dc.subjectRats.en
dc.titleChronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques - spectroscopy and perfusionen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-197783en
sync.item.dbtypeVAVen
sync.item.insts2025.06.10 13:55:59en
sync.item.modts2025.06.10 13:32:59en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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