The distribution of antibiotic resistance genes in chicken gut microbiota commensals
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Date
2021-02-08
Authors
Juřicová, Helena
Matiašovicová, Jitka
Kubasová, Tereza
Čejková, Darina
Rychlík, Ivan
ORCID
0000-0002-6989-6330Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Nature
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Abstract
Antibiotic resistance in bacterial pathogens or several indicator bacteria is commonly studied but the extent of antibiotic resistance in bacterial commensals colonising the intestinal tract is essentially unknown. In this study, we aimed to investigate the presence of horizontally acquired antibiotic resistance genes among chicken gut microbiota members in 259 isolates with known whole genomic sequences. Altogether 124 isolates contained at least one gene coding for antibiotic resistance. Genes coding for the resistance to tetracyclines (detected in 101 isolates), macrolide-lincosamide-streptogramin B antibiotics (28 isolates) and aminoglycosides (25 isolates) were the most common. The most frequent tetracycline resistance genes were tet(W), tet(32), tet(O) and tet(Q). Lachnospiraceae and Ruminococcaceae frequently encoded tet(W). Lachnospiraceae commonly coded also for tet(32) and tet(O). The tet(44) gene was associated with Erysipelotrichaceae and tet(Q) was detected in the genomes of Bacteroidaceae and Porphyromonadaceae. Without any bias we have shown that antibiotic resistance is quite common in gut commensals. However, a comparison of codon usage showed that the above-mentioned families represent the most common current reservoirs but probably not the original host of the detected resistances.
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Citation
Scientific Reports. 2021, vol. 11, issue 1, p. 1-10.
https://www.nature.com/articles/s41598-021-82640-3
https://www.nature.com/articles/s41598-021-82640-3
Document type
Peer-reviewed
Document version
Published version
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Language of document
en