Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies

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dc.contributor.authorBalzekas, Irenacs
dc.contributor.authorSladký, Vladimírcs
dc.contributor.authorNejedlý, Petrcs
dc.contributor.authorBrinkmann, Benjamin H.cs
dc.contributor.authorCrepeau, Danielcs
dc.contributor.authorMívalt, Filipcs
dc.contributor.authorGregg, Nicholas M.cs
dc.contributor.authorAttia, Tal Palcs
dc.contributor.authorMarks, Victoria S.cs
dc.contributor.authorWheeler, Lydia P.cs
dc.contributor.authorRicelli, Tori E.cs
dc.contributor.authorStaab, Jeffrey P.cs
dc.contributor.authorLundstrom, Briancs
dc.contributor.authorMiller, Kai J.cs
dc.contributor.authorVan Gompel, Jamie J.cs
dc.contributor.authorKřemen, Václavcs
dc.contributor.authorCroarkin, Paul E.cs
dc.contributor.authorWorrell, Gregorycs
dc.coverage.issue1cs
dc.coverage.volume15cs
dc.date.issued2021-07-26cs
dc.description.abstractIntracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug-resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental in studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.en
dc.formattextcs
dc.format.extent1-17cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationFrontiers in Human Neuroscience. 2021, vol. 15, issue 1, p. 1-17.en
dc.identifier.doi10.3389/fnhum.2021.702605cs
dc.identifier.issn1662-5161cs
dc.identifier.orcid0000-0002-0693-9495cs
dc.identifier.other172290cs
dc.identifier.researcheridAAX-1872-2021cs
dc.identifier.scopus57205062706cs
dc.identifier.urihttp://hdl.handle.net/11012/203033
dc.language.isoencs
dc.publisherFrontiers Mediacs
dc.relation.ispartofFrontiers in Human Neurosciencecs
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fnhum.2021.702605/fullcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1662-5161/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectepilepsyen
dc.subjectpsychiatric disordersen
dc.subjectmajor depression (MDD)en
dc.subjectSEEG (stereoelectroencephalography)en
dc.subjectelectrocorticography (ECoG)en
dc.subjectdeep brain stimulationen
dc.subjectbiomarkeren
dc.subjectneuromodulationen
dc.titleInvasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologiesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172290en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:51en
sync.item.modts2025.01.17 19:34:44en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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