Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

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dc.contributor.authorJuříková, Lenkacs
dc.contributor.authorMasárová, Luciacs
dc.contributor.authorPanovský, Romancs
dc.contributor.authorPešl, Martincs
dc.contributor.authorŽondra Revendová, Kamilacs
dc.contributor.authorVolný, Ondřejcs
dc.contributor.authorFeitová, Věracs
dc.contributor.authorHoleček, Tomášcs
dc.contributor.authorKincl, Vladimírcs
dc.contributor.authorDanhofer, Pavlínacs
dc.contributor.authorVoháňka, Stanislavcs
dc.contributor.authorHaberlová, Janacs
dc.contributor.authorPodolská, Karolínacs
dc.coverage.issue2cs
dc.coverage.volume15cs
dc.date.accessioned2024-05-13T11:46:01Z
dc.date.available2024-05-13T11:46:01Z
dc.date.issued2024-02-08cs
dc.description.abstractIn this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8-18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.en
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationFrontiers in Neurology. 2024, vol. 15, issue 2, p. 1-11.en
dc.identifier.doi10.3389/fneur.2024.1360385cs
dc.identifier.issn1664-2295cs
dc.identifier.orcid0000-0001-8805-668Xcs
dc.identifier.other188247cs
dc.identifier.urihttps://hdl.handle.net/11012/245500
dc.language.isoencs
dc.publisherFRONTIERS MEDIA SAcs
dc.relation.ispartofFrontiers in Neurologycs
dc.relation.urihttps://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/fullcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1664-2295/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectquality of lifeen
dc.subjectDuchenne muscular dystrophyen
dc.subjectcardiac magnetic resonanceen
dc.subjectneurological statusen
dc.subjectcardiac impairmenten
dc.titleDecreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairmenten
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188247en
sync.item.dbtypeVAVen
sync.item.insts2024.05.13 13:46:01en
sync.item.modts2024.05.13 13:14:25en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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