The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

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dc.contributor.authorFarkas, Árpádcs
dc.contributor.authorLízal, Františekcs
dc.contributor.authorJedelský, Jancs
dc.contributor.authorElcner, Jakubcs
dc.contributor.authorKaras, Jakubcs
dc.contributor.authorBělka, Miloslavcs
dc.contributor.authorMišík, Ondrejcs
dc.contributor.authorJícha, Miroslavcs
dc.coverage.issue1cs
dc.coverage.volume147cs
dc.date.issued2020-07-10cs
dc.description.abstractQuantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively. There was a good agreement between the experimental and simulation deposition results also in the different predefined sections of the airways. Present pilot study proved that lobar flow redistribution due to severe asthma significantly modified the deposition distribution of micro-particles. Although the present results refer only to small groups of healthy and asthmatic individuals, it clearly demonstrates the capability of carefully validated models to simulate the deposition of micron-size particles in larger populations of both groups.en
dc.formattextcs
dc.format.extent1-16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJOURNAL OF AEROSOL SCIENCE. 2020, vol. 147, issue 1, p. 1-16.en
dc.identifier.doi10.1016/j.jaerosci.2020.105582cs
dc.identifier.issn0021-8502cs
dc.identifier.orcid0000-0002-0389-608Xcs
dc.identifier.orcid0000-0002-1268-8434cs
dc.identifier.orcid0000-0001-9287-4458cs
dc.identifier.orcid0000-0001-8905-9751cs
dc.identifier.orcid0000-0003-4683-5145cs
dc.identifier.orcid0000-0002-1409-5165cs
dc.identifier.other164472cs
dc.identifier.researcheridD-4363-2018cs
dc.identifier.researcheridA-9224-2013cs
dc.identifier.researcheridI-3748-2018cs
dc.identifier.researcheridCVT-7747-2022cs
dc.identifier.scopus54966786300cs
dc.identifier.scopus23090535800cs
dc.identifier.scopus55090074500cs
dc.identifier.scopus6602494673cs
dc.identifier.urihttp://hdl.handle.net/11012/191378
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofJOURNAL OF AEROSOL SCIENCEcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihubcs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0021-8502/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectAEROSOL DEPOSITIONen
dc.subjectHUMAN AIRWAYSen
dc.subjectLUNG-FUNCTIONen
dc.subjectFLOWen
dc.titleThe role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjectsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164472en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:47:11en
sync.item.modts2025.01.17 20:33:10en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. EÚ-odbor termomechaniky a techniky prostředícs
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