Antimicrobial Cost-Effective Transparent Hydrogel Films from Renewable Gum Karaya/Chitosan Polysaccharides for Modern Wound Dressings

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dc.contributor.authorDrápalová, Evacs
dc.contributor.authorMichlovská, Lenkacs
dc.contributor.authorPoštulková, Hanacs
dc.contributor.authorChamradová, Ivanacs
dc.contributor.authorLipový, Břetislavcs
dc.contributor.authorHoloubek, Jakubcs
dc.contributor.authorVacek, Lukášcs
dc.contributor.authorRůžička, Filipcs
dc.contributor.authorHanslianová, Markétacs
dc.contributor.authorSvobodová, Táňacs
dc.contributor.authorČerná, Evacs
dc.contributor.authorHrdličková, Barbaracs
dc.contributor.authorVojtová, Lucycs
dc.coverage.issue4cs
dc.coverage.volume5cs
dc.date.accessioned2023-08-01T10:58:33Z
dc.date.available2023-08-01T10:58:33Z
dc.date.issued2023-04-14cs
dc.description.abstractThe newest trends in wound healing management and the development of the next generation of dressings are pointing toward natural polymeric materials with important beneficial properties such as antimicrobial effects, renewability, easier process of preparation, and biological activity. Here, we present the preparation and in vitro evaluation of a unique biopolymeric blend composed of natural polymers based on the positively charged polysaccharide chitosan and negatively charged gum karaya. A plate lysis assay of gum karaya and chitosan solution mixtures proved the synergistic antimicrobial effect against specific strains of both Gram-positive and Gram-negative bacteria and yeast. This polymeric mixture was used for hydrogel film preparation and determination of the composition effect on physical properties (swelling behavior in different solvents, pH, diffusion mechanism, hydrolytic stability, mechanical and optical properties). While the pure gum karaya with poly(vinyl alcohol) exhibited the highest hydrolytic degradation (68%), the mixture of poly(vinyl alcohol) and gum karaya with chitosan (in the 25:75 ratio) exhibited the lowest degradation value (41%) due to the strong physical interactions. Cytotoxicity tests performed with hydrogel extracts using two different in vitro models, adherent fibroblasts (NIH3T3) and non-adherent suspension B-lymphocytes (BaF3), exhibited excellent biocompatibility and no cytotoxicity. As expected, the antimicrobial activity of 3-day film extracts showed a significantly improved antimicrobial effect of mixtures involving a chitosan biopolymer. The physical and biological properties of prepared biopolymer-based hydrogels meet the requirements of modern wound dressings.en
dc.formattextcs
dc.format.extent2774-2786cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS APPLIED POLYMER MATERIALS. 2023, vol. 5, issue 4, p. 2774-2786.en
dc.identifier.doi10.1021/acsapm.3c00025cs
dc.identifier.issn2637-6105cs
dc.identifier.orcid0000-0002-7963-1715cs
dc.identifier.orcid0000-0003-3736-2825cs
dc.identifier.orcid0000-0001-7927-946Xcs
dc.identifier.orcid0000-0002-2969-8460cs
dc.identifier.orcid0000-0001-5281-7045cs
dc.identifier.other183757cs
dc.identifier.researcheridB-1133-2014cs
dc.identifier.researcheridD-7762-2012cs
dc.identifier.scopus25621760100cs
dc.identifier.scopus12039667200cs
dc.identifier.urihttp://hdl.handle.net/11012/213684
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS APPLIED POLYMER MATERIALScs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsapm.3c00025cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2637-6105/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectnatural gumen
dc.subjectpolysaccharidesen
dc.subjectbiopolymersen
dc.subjectantibacterial activityen
dc.subjectcytotoxicityen
dc.titleAntimicrobial Cost-Effective Transparent Hydrogel Films from Renewable Gum Karaya/Chitosan Polysaccharides for Modern Wound Dressingsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183757en
sync.item.dbtypeVAVen
sync.item.insts2023.09.11 12:56:03en
sync.item.modts2023.09.11 12:14:47en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
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