In silico Analysis of Rutin from Ruta chalepensis.L for NF-X1 Inhibition in Cervical Cancer: Insights from HPTLC studies

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but.event.date23.04.2024cs
but.event.titleSTUDENT EEICT 2024cs
dc.contributor.authorRajasekaran, Laxmipriya
dc.contributor.authorPankaj, Vaishali
dc.contributor.authorBhogal, Inderjeet
dc.contributor.authorČejková, Darina
dc.date.accessioned2024-07-09T07:38:39Z
dc.date.available2024-07-09T07:38:39Z
dc.date.issued2024cs
dc.description.abstractBioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids, flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.en
dc.formattextcs
dc.format.extent207-210cs
dc.format.mimetypeapplication/pdfen
dc.identifier.citationProceedings I of the 30st Conference STUDENT EEICT 2024: General papers. s. 207-210. ISBN 978-80-214-6231-1cs
dc.identifier.isbn978-80-214-6231-1
dc.identifier.issn2788-1334
dc.identifier.urihttps://hdl.handle.net/11012/249236
dc.language.isoencs
dc.publisherVysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.relation.ispartofProceedings I of the 30st Conference STUDENT EEICT 2024: General papersen
dc.relation.urihttps://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2024_sbornik_1.pdfcs
dc.rights© Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.rights.accessopenAccessen
dc.subjectRuta chalepensis. Len
dc.subjectRutinen
dc.subjectHPTLCen
dc.subjectNF-X1en
dc.subjectin silicoen
dc.titleIn silico Analysis of Rutin from Ruta chalepensis.L for NF-X1 Inhibition in Cervical Cancer: Insights from HPTLC studiesen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
eprints.affiliatedInstitution.departmentFakulta elektrotechniky a komunikačních technologiícs
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