Experimental model of occluded biliary metal stent recanalization using irreversible electroporation via a tubular catheter

Simple item page
dc.contributor.authorRohan, Tomášcs
dc.contributor.authorAndrašína, Tomášcs
dc.contributor.authorJůza, Tomášcs
dc.contributor.authorMatkulčík, Petercs
dc.contributor.authorNovotná, Veronikacs
dc.contributor.authorČervinka, Daliborcs
dc.contributor.authorBernard, Vladancs
dc.contributor.authorVálek, Vlastimilcs
dc.contributor.authorNahum Goldberg, Shragacs
dc.coverage.issue1cs
dc.coverage.volume38cs
dc.date.accessioned2021-12-14T15:55:53Z
dc.date.available2021-12-14T15:55:53Z
dc.date.issued2021-03-07cs
dc.description.abstractPurpose To demonstrate the feasibility of irreversible electroporation (IRE) for treating biliary metal stent occlusion in an experimental liver model. Methods and materials IRE was performed using an expandable tubular IRE-catheter placed in nitinol stents in the porcine liver. A 3-electrode IRE-catheter was connected to an IRE-generator and one hundred 100 mu s pulses of constant voltage (300, 650, 1000, and 1300 V) were applied. Stent occlusion was simulated by insertion of liver tissue both ex vivo (n = 94) and in vivo in 3 pigs (n = 14). Three scenarios of the relationship between the stent, electrodes, and inserted tissue (double contact, single contact, and stent mesh contact) were studied. Electric current was measured and resistance and power calculated. Pigs were sacrificed 72 h post-procedure. Harvested samples (14 experimental, 13 controls) underwent histopathological analysis. Results IRE application was feasible at 300 and 650 V for the single and double contact setup in both ex vivo and in vivo studies. Significant differences in calculated resistance between double contact and single contact settings were observed (ex-vivo p < 0.0001, in-vivo p = 0.02; Mann-Whitney). A mild temperature increase of the surrounding liver parenchyma was noted with increasing voltage (0.9-5.9 degrees C for 300-1000 V). The extent of necrotic changes in experimental samples in vivo correlated with the measured electric current (r (2) = 0.39, p = 0.01). No complications were observed during or after the in-vivo procedure. Conclusion Endoluminal IRE using an expandable tubular catheter in simulated metal stent occlusion is feasible. The relationship of active catheter electrodes to stent ingrowth tissue can be estimated based on resistance values.en
dc.formattextcs
dc.format.extent393-401cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Hyperthermia. 2021, vol. 38, issue 1, p. 393-401.en
dc.identifier.doi10.1080/02656736.2021.1875061cs
dc.identifier.issn1464-5157cs
dc.identifier.other171446cs
dc.identifier.urihttp://hdl.handle.net/11012/203214
dc.language.isoencs
dc.publisherTaylor & Franciscs
dc.relation.ispartofInternational Journal of Hyperthermiacs
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/02656736.2021.1875061cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1464-5157/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectIrreversible electroporationen
dc.subjectmetal stent occlusionen
dc.subjectmetal stent recanalizationen
dc.subjectexperimental modelen
dc.subjectthermocameraen
dc.titleExperimental model of occluded biliary metal stent recanalization using irreversible electroporation via a tubular catheteren
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-171446en
sync.item.dbtypeVAVen
sync.item.insts2022.02.03 12:53:18en
sync.item.modts2022.02.03 12:14:11en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav výkonové elektrotechniky a elektronikycs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rohan_2021.pdf
Size:
2.48 MB
Format:
Adobe Portable Document Format
Description:
Rohan_2021.pdf
Download
Collections
Ústav výkonové elektrotechniky a elektroniky