Ultrathin TiO2 Coatings via Atomic Layer Deposition Strongly Improve Cellular Interactions on Planar and Nanotubular Biomedical Ti Substrates
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Date
2024-01-26
Authors
Čapek, Jan
Sepúlveda Sepúlveda, Lina Marcela
Báčová, Jana
Rodriguez Pereira, Jhonatan
Zazpe Mendioroz, Raúl
Čičmancová, Veronika
Nývltová, Pavlína
Handl, Jiří
Knotek, Petr
Baishya, Kaushik
ORCID
0000-0001-7091-3022Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
AMER CHEMICAL SOC
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Abstract
This work aims to investigate the chemical and/or structural modification of Ti and Ti-6Al-4V (TiAlV) alloy surfaces to possess even more favorable properties toward cell growth. These modifications were achieved by (i) growing TiO2 nanotube layers on these substrates by anodization, (ii) surface coating by ultrathin TiO2 atomic layer deposition (ALD), or (iii) by the combination of both. In particular, an ultrathin TiO2 coating, achieved by 1 cycle of TiO2 ALD, was intended to shade the impurities of F- and V-based species in tested materials while preserving the original structure and morphology. The cell growth on TiO2-coated and uncoated TiO2 nanotube layers, Ti foils, and TiAlV alloy foils were compared after incubation for up to 72 h. For evaluation of the biocompatibility of tested materials, cell lines of different tissue origin, including predominantly MG-63 osteoblastic cells, were used. For all tested nanomaterials, adding an ultrathin TiO2 coating improved the growth of MG-63 cells and other cell lines compared with the non-TiO2-coated counterparts. Here, the presented approach of ultrathin TiO2 coating could be used potentially for improving implants, especially in terms of shading problematic F- and V-based species in TiO2 nanotube layers.
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Citation
ACS applied materials & interfaces. 2024, vol. 16, issue 5, p. 5627-5636.
https://pubs.acs.org/doi/10.1021/acsami.3c17074
https://pubs.acs.org/doi/10.1021/acsami.3c17074
Document type
Peer-reviewed
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Published version
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en