Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

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dc.contributor.authorSiemaszko, Jagodacs
dc.contributor.authorMarzec-Przyszlak, Aleksandracs
dc.contributor.authorBogunia-Kubik, Katarzynacs
dc.coverage.issue1cs
dc.coverage.volume71cs
dc.date.issued2023-03-10cs
dc.description.abstractThe interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2023, vol. 71, issue 1, p. 1-18.en
dc.identifier.doi10.1007/s00005-023-00674-zcs
dc.identifier.issn0004-069Xcs
dc.identifier.other183147cs
dc.identifier.urihttp://hdl.handle.net/11012/213623
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIScs
dc.relation.urihttps://link.springer.com/article/10.1007/s00005-023-00674-zcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0004-069X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectNK cell receptorsen
dc.subjectimmunotherapyen
dc.subjectliganden
dc.titleActivating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applicationsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183147en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:56en
sync.item.modts2025.01.17 16:48:17en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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