Cell type specificity of neurovascular coupling in cerebral cortex

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dc.contributor.authorUhlířová, Hanacs
dc.contributor.authorKlç, Kvlcmcs
dc.contributor.authorTian, Pfeifangcs
dc.contributor.authorThunemann, Martincs
dc.contributor.authorDesjardins, Michelecs
dc.contributor.authorSaisan, Payam A.cs
dc.contributor.authorSakadžic, Savacs
dc.contributor.authorNess, Torbjrn Vcs
dc.contributor.authorMateo, Celinecs
dc.contributor.authorCheng, Quncs
dc.contributor.authorWeldy, Kimberly L.cs
dc.contributor.authorRazoux, Florencecs
dc.contributor.authorVandenberghe, Matthieucs
dc.contributor.authorCremonesi, Jonathan Acs
dc.contributor.authorFerri, Christopher GLcs
dc.contributor.authorNizar, Krystalcs
dc.contributor.authorSridhar, Vishnu B.cs
dc.contributor.authorSteed, Tyler C.cs
dc.contributor.authorAbashin, Maximcs
dc.contributor.authorFainman, Yeshaiahucs
dc.contributor.authorMasliah, Eliezercs
dc.contributor.authorDjurovic, Srdjancs
dc.contributor.authorAndreassen, Ola Acs
dc.contributor.authorSilva, Gabriel A.cs
dc.contributor.authorBoas, David A.cs
dc.contributor.authorKleinfeld, Davidcs
dc.contributor.authorBuxton, Richard Bcs
dc.contributor.authorEinevoll, Gaute T.cs
dc.contributor.authorDale, Anders M.cs
dc.contributor.authorDevor, Annacs
dc.coverage.issue1cs
dc.coverage.volume5cs
dc.date.accessioned2022-05-18T10:51:48Z
dc.date.available2022-05-18T10:51:48Z
dc.date.issued2016-05-31cs
dc.description.abstractIdentification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.en
dc.formattextcs
dc.format.extent1-23cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationeLife. 2016, vol. 5, issue 1, p. 1-23.en
dc.identifier.doi10.7554/elife.14315cs
dc.identifier.issn2050-084Xcs
dc.identifier.other126695cs
dc.identifier.urihttp://hdl.handle.net/11012/204286
dc.language.isoencs
dc.publishereLife Sciences Publicationscs
dc.relation.ispartofeLifecs
dc.relation.urihttps://elifesciences.org/content/5/e14315cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2050-084X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectcerebrovascular regulationen
dc.subject2-photon imagingen
dc.titleCell type specificity of neurovascular coupling in cerebral cortexen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-126695en
sync.item.dbtypeVAVen
sync.item.insts2022.05.18 12:51:48en
sync.item.modts2022.05.18 12:14:11en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Experimentální biofotonikacs
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