Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation

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dc.contributor.authorRobertson, Jamescs
dc.contributor.authorCox, Bencs
dc.contributor.authorJaroš, Jiřícs
dc.contributor.authorTreeby, Bradleycs
dc.coverage.issue3cs
dc.coverage.volume141cs
dc.date.issued2017-03-13cs
dc.description.abstractNon-invasive, focal neurostimulation with ultrasound is a potentially powerful neuroscientific tool that requires effective transcranial focusing of ultrasound to develop. Time-reversal (TR) focusing using numerical simulations of transcranial ultrasound propagation can correct for the effect of the skull, but relies on accurate simulations. Here, focusing requirements for ultrasonic neurostimulation are established through a review of previously employed ultrasonic parameters, and consideration of deep brain targets. The specific limitations of finite-difference time domain (FDTD) and k-space corrected pseudospectral time domain (PSTD) schemes are tested numerically to establish the spatial points per wavelength and temporal points per period needed to achieve the desired accuracy while minimizing the computational burden. These criteria are confirmed through convergence testing of a fully simulated TR protocol using a virtual skull. The k-space PSTD scheme performed as well as, or better than, the widely used FDTD scheme across all individual error tests and in the convergence of large scale models, recommending it for use in simulated TR. Staircasing was shown to be the most serious source of error. Convergence testing indicated that higher sampling is required to achieve fine control of the pressure amplitude at the target than is needed for accurate spatial targeting.en
dc.description.abstractNeinvazivní neurostimulace pomocí ultrazvuku je nové technika s širokým uplatněním při výzkumu mozku. Tato práce vyšetřuje možnosti cíleného zaměření svazku ultrazvukových vln a korekce aberací způsobné průchodem skrze lebkucs
dc.formattextcs
dc.format.extent1726-1738cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJournal of the Acoustical Society of America. 2017, vol. 141, issue 3, p. 1726-1738.en
dc.identifier.doi10.1121/1.4976339cs
dc.identifier.issn1520-8524cs
dc.identifier.orcid0000-0002-0087-8804cs
dc.identifier.other134713cs
dc.identifier.researcheridH-2445-2016cs
dc.identifier.scopus13408713400cs
dc.identifier.urihttp://hdl.handle.net/11012/68367
dc.language.isoencs
dc.relation.ispartofJournal of the Acoustical Society of Americacs
dc.relation.urihttp://asa.scitation.org/doi/10.1121/1.4976339cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1520-8524/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectTranscranial neurostimulationen
dc.subjectfocused ultrasounden
dc.subjectnumerical simulationen
dc.subjectTranskraniální stimulace
dc.subjectfokusovaný ultrazvuk
dc.subjectnumerická simulace
dc.titleAccurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulationen
dc.title.alternativeTranskraniální simulací šíření ultrazvuku skrze lebku pro neuromodulaci a neurostimulacics
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-134713en
sync.item.dbtypeVAVen
sync.item.insts2024.03.25 03:46:05en
sync.item.modts2024.03.25 03:14:12en
thesis.grantorVysoké učení technické v Brně. Fakulta informačních technologií. Ústav počítačových systémůcs
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