Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

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dc.contributor.authorLízal, Františekcs
dc.contributor.authorJedelský, Jancs
dc.contributor.authorAdam, Jancs
dc.contributor.authorBělka, Miloslavcs
dc.contributor.authorJícha, Miroslavcs
dc.coverage.issue1cs
dc.coverage.volume45cs
dc.date.issued2013-04-09cs
dc.description.abstractPositron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.en
dc.description.abstractPositron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.en
dc.formattextcs
dc.format.extent1-4cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEPJ Web of Conferences. 2013, vol. 45, issue 1, p. 1-4.en
dc.identifier.doi10.1051/epjconf/20134501060cs
dc.identifier.isbn978-80-7372-912-7cs
dc.identifier.issn2100-014Xcs
dc.identifier.orcid0000-0002-0389-608Xcs
dc.identifier.orcid0000-0002-1268-8434cs
dc.identifier.orcid0000-0001-8905-9751cs
dc.identifier.orcid0000-0002-1409-5165cs
dc.identifier.other95329cs
dc.identifier.researcheridD-4363-2018cs
dc.identifier.researcheridA-9224-2013cs
dc.identifier.researcheridCVT-7747-2022cs
dc.identifier.scopus54966786300cs
dc.identifier.scopus23090535800cs
dc.identifier.scopus6602494673cs
dc.identifier.urihttp://hdl.handle.net/11012/193652
dc.language.isoencs
dc.publisherEDP Sciencescs
dc.relation.ispartofEPJ Web of Conferencescs
dc.relation.urihttps://www.epj-conferences.org/articles/epjconf/abs/2013/06/epjconf_efm2013_01060/epjconf_efm2013_01060.htmlcs
dc.rightsCreative Commons Attribution 2.0 Genericcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2100-014X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/cs
dc.subjectaerosol transporten
dc.subjectaerosol depositionen
dc.subjectpositron emission tomographyen
dc.subjecthuman lung modelen
dc.subjectaerosol transport
dc.subjectaerosol deposition
dc.subjectpositron emission tomography
dc.subjecthuman lung model
dc.titleApplication of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungsen
dc.title.alternativeApplication of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungsen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-95329en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 14:52:15en
sync.item.modts2025.10.14 10:47:47en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Energetický ústavcs
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