Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

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dc.contributor.authorBezrouk, Alešcs
dc.contributor.authorHosszú, Tomášcs
dc.contributor.authorHromádko, Luděkcs
dc.contributor.authorOlmrová Zmrhalová, Zuzanacs
dc.contributor.authorKopeček, Martincs
dc.contributor.authorSmutný, Martincs
dc.contributor.authorKrulichová, Iva Selkecs
dc.contributor.authorMacák, Jancs
dc.contributor.authorKremláček, Jancs
dc.coverage.issue7cs
dc.coverage.volume15cs
dc.date.issued2020-07-08cs
dc.description.abstractBiodegradable stents are promising treatments for many diseases, e.g., coronary artery disease, urethral diseases, tracheal diseases, and esophageal strictures. The mechanical properties of biodegradable stent materials play a key role in the safety and efficacy of treatment. In particular, insufficient creep resistance of the stent material could result in premature stent collapse or narrowing. Commercially available biodegradable self-expandable SX-ELLA stents made of polydioxanone monofilament were tested. A new, simple, and affordable method to measure the shear modulus of tiny viscoelastic wires is presented. The important mechanical parameters of the polydioxanone filament were obtained: the median Young's modulus was (E) over tilde = 958 (922, 974) MPa and the shear modulus was (G) over tilde= 357 (185, 387) MPa, resulting in a Poisson's ratio of nu = 0.34. The SX-ELLA stents exhibited significant force relaxation due to the stress relaxation of the polydioxanone monofilament, approximately 19% and 36% 10 min and 48 h after stent application, respectively. However, these results were expected, and the manufacturer and implanting clinician should be aware of the known behavior of these biodegradable materials. If possible, a biodegradable stent should be designed considering therapeutic force rather than initial force. Additionally, new and more advanced biodegradable shape-memory polymers should be considered for future study and use.en
dc.description.abstractBiodegradable stents are promising treatments for many diseases, e.g., coronary artery disease, urethral diseases, tracheal diseases, and esophageal strictures. The mechanical properties of biodegradable stent materials play a key role in the safety and efficacy of treatment. In particular, insufficient creep resistance of the stent material could result in premature stent collapse or narrowing. Commercially available biodegradable self-expandable SX-ELLA stents made of polydioxanone monofilament were tested. A new, simple, and affordable method to measure the shear modulus of tiny viscoelastic wires is presented. The important mechanical parameters of the polydioxanone filament were obtained: the median Young's modulus was (E) over tilde = 958 (922, 974) MPa and the shear modulus was (G) over tilde= 357 (185, 387) MPa, resulting in a Poisson's ratio of nu = 0.34. The SX-ELLA stents exhibited significant force relaxation due to the stress relaxation of the polydioxanone monofilament, approximately 19% and 36% 10 min and 48 h after stent application, respectively. However, these results were expected, and the manufacturer and implanting clinician should be aware of the known behavior of these biodegradable materials. If possible, a biodegradable stent should be designed considering therapeutic force rather than initial force. Additionally, new and more advanced biodegradable shape-memory polymers should be considered for future study and use.en
dc.formattextcs
dc.format.extent1-16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLoS One. 2020, vol. 15, issue 7, p. 1-16.en
dc.identifier.doi10.1371/journal.pone.0235842cs
dc.identifier.issn1932-6203cs
dc.identifier.orcid0000-0001-7091-3022cs
dc.identifier.other170376cs
dc.identifier.scopus34872408700cs
dc.identifier.scopus55655855500cs
dc.identifier.urihttp://hdl.handle.net/11012/196572
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLoS Onecs
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235842cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBENIGN ESOPHAGEAL STRICTURESen
dc.subjectSUTURE MATERIALSen
dc.subjectMEMORYen
dc.subjectDEGRADATIONen
dc.subjectCOMPOSITESen
dc.subjectSTRENGTHen
dc.subjectBEHAVIORen
dc.subjectFIBERSen
dc.subjectMODELSen
dc.subjectCREEPen
dc.subjectBENIGN ESOPHAGEAL STRICTURES
dc.subjectSUTURE MATERIALS
dc.subjectMEMORY
dc.subjectDEGRADATION
dc.subjectCOMPOSITES
dc.subjectSTRENGTH
dc.subjectBEHAVIOR
dc.subjectFIBERS
dc.subjectMODELS
dc.subjectCREEP
dc.titleMechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevanceen
dc.title.alternativeMechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevanceen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-170376en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 15:19:02en
sync.item.modts2025.10.14 10:36:15en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé nízkodimenzionální nanomateriálycs
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