Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

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dc.contributor.authorBezrouk, Alešcs
dc.contributor.authorHosszú, Tomášcs
dc.contributor.authorHromádko, Luděkcs
dc.contributor.authorOlmrová Zmrhalová, Zuzanacs
dc.contributor.authorKopeček, Martincs
dc.contributor.authorSmutný, Martincs
dc.contributor.authorKrulichová, Iva Selkecs
dc.contributor.authorMacák, Jancs
dc.contributor.authorKremláček, Jancs
dc.coverage.issue7cs
dc.coverage.volume15cs
dc.date.accessioned2021-04-22T10:54:15Z
dc.date.available2021-04-22T10:54:15Z
dc.date.issued2020-07-08cs
dc.description.abstractBiodegradable stents are promising treatments for many diseases, e.g., coronary artery disease, urethral diseases, tracheal diseases, and esophageal strictures. The mechanical properties of biodegradable stent materials play a key role in the safety and efficacy of treatment. In particular, insufficient creep resistance of the stent material could result in premature stent collapse or narrowing. Commercially available biodegradable self-expandable SX-ELLA stents made of polydioxanone monofilament were tested. A new, simple, and affordable method to measure the shear modulus of tiny viscoelastic wires is presented. The important mechanical parameters of the polydioxanone filament were obtained: the median Young's modulus was (E) over tilde = 958 (922, 974) MPa and the shear modulus was (G) over tilde= 357 (185, 387) MPa, resulting in a Poisson's ratio of nu = 0.34. The SX-ELLA stents exhibited significant force relaxation due to the stress relaxation of the polydioxanone monofilament, approximately 19% and 36% 10 min and 48 h after stent application, respectively. However, these results were expected, and the manufacturer and implanting clinician should be aware of the known behavior of these biodegradable materials. If possible, a biodegradable stent should be designed considering therapeutic force rather than initial force. Additionally, new and more advanced biodegradable shape-memory polymers should be considered for future study and use.en
dc.formattextcs
dc.format.extent1-16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS ONE. 2020, vol. 15, issue 7, p. 1-16.en
dc.identifier.doi10.1371/journal.pone.0235842cs
dc.identifier.issn1932-6203cs
dc.identifier.other170376cs
dc.identifier.urihttp://hdl.handle.net/11012/196572
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235842cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBENIGN ESOPHAGEAL STRICTURESen
dc.subjectSUTURE MATERIALSen
dc.subjectMEMORYen
dc.subjectDEGRADATIONen
dc.subjectCOMPOSITESen
dc.subjectSTRENGTHen
dc.subjectBEHAVIORen
dc.subjectFIBERSen
dc.subjectMODELSen
dc.subjectCREEPen
dc.titleMechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevanceen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-170376en
sync.item.dbtypeVAVen
sync.item.insts2021.04.22 12:54:15en
sync.item.modts2021.04.22 12:14:36en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé nízkodimenzionální nanomateriálycs
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