Piezoelectric Polyvinylidene Fluoride Nanofibers as a Scaffold used for Bone Tissue Engineering

Abstract

The field of bone tissue engineering deals with the issue of developing compatible and non-toxic scaffolds, which provide the growing bone cells with the necessary mechanical support and suitable stimulation for proper growth and proliferation. Polyvinylidene fluoride (PVDF) nanofibers are considered to be a suitable scaffold due to their biocompatibility, fibrous structure, and characteristic piezoelectric properties, which have proven to be an important factor in cell regeneration. For this work, flexible PVDF nanofibers were successfully spun, from which the scaffolding needed for the subsequent settling of cultivated osteoblasts was created. Thereafter the structure and compatibility of this nanomaterial were assessed in relation to the study of cell adhesion to individual nanofibers.