Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: A longitudinal electroencephalography investigation

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dc.contributor.authorDell, Katrina L.cs
dc.contributor.authorPayne, Daniel E.cs
dc.contributor.authorKřemen, Václavcs
dc.contributor.authorMaturana, Matias I.cs
dc.contributor.authorGerla, Václavcs
dc.contributor.authorNejedlý, Petrcs
dc.contributor.authorWorrell, Gregorycs
dc.contributor.authorLhotska, Lenkacs
dc.contributor.authorMívalt, Filipcs
dc.contributor.authorBoston, Raymond C.cs
dc.contributor.authorBrinkmann, Benjamin H.cs
dc.contributor.authorWendyl, D'Souzacs
dc.contributor.authorBurkitt, Anthony N.cs
dc.contributor.authorGrayden, David B.cs
dc.contributor.authorKuhlmann, Levincs
dc.contributor.authorFreestone, Dean R.cs
dc.contributor.authorCook, Mark J.cs
dc.coverage.issue7cs
dc.coverage.volume37cs
dc.date.issued2021-07-01cs
dc.description.abstractBackground: While the effects of prolonged sleep deprivation (24 h) on seizure occurrence has been thoroughly explored, little is known about the effects of day-to-day variations in the duration and quality of sleep on seizure probability. A better understanding of the interaction between sleep and seizures may help to improve seizure management. Methods: To explore how sleep and epileptic seizures are associated, we analysed continuous intracranial electroencephalography (EEG) recordings collected from 10 patients with refractory focal epilepsy undergoing ordinary life activities between 2010 and 2012 from three clinical centres (Austin Health, The Royal Melbourne Hospital, and St Vincent's Hospital of the Melbourne University Epilepsy Group). A total of 4340 days of sleep-wake data were analysed (average 434 days per patient). EEG data were sleep scored using a semi-automated machine learning approach into wake, stages one, two, and three non-rapid eye movement sleep, and rapid eye movement sleep categories. Findings: Seizure probability changes with day-to-day variations in sleep duration. Logistic regression models revealed that an increase in sleep duration, by 1·66 ± 0·52 h, lowered the odds of seizure by 27% in the following 48 h. Following a seizure, patients slept for longer durations and if a seizure occurred during sleep, then sleep quality was also reduced with increased time spent aroused from sleep and reduced rapid eye movement sleep. Interpretation: Our results suggest that day-to-day deviations from regular sleep duration correlates with changes in seizure probability. Sleeping longer, by 1·66 ± 0·52 h, may offer protective effects for patients with refractory focal epilepsy, reducing seizure risk. Furthermore, the occurrence of a seizure may disrupt sleep patterns by elongating sleep and, if the seizure occurs during sleep, reducing its quality.en
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEClinicalMedicine. 2021, vol. 37, issue 7, p. 1-12.en
dc.identifier.doi10.1016/J.ECLINM.2021.100934cs
dc.identifier.issn2589-5370cs
dc.identifier.orcid0000-0002-0693-9495cs
dc.identifier.other172327cs
dc.identifier.researcheridAAX-1872-2021cs
dc.identifier.scopus57205062706cs
dc.identifier.urihttp://hdl.handle.net/11012/201545
dc.language.isoencs
dc.publisherThe Lancet Publishing Groupcs
dc.relation.ispartofEClinicalMedicinecs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2589537021002145cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2589-5370/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectEpilepsyen
dc.subjectSeizuresen
dc.subjectConvulsionsen
dc.subjectSleepen
dc.subjectSleep qualityen
dc.subjectSleep durationen
dc.subjectSleep compositionen
dc.subjectSleep architectureen
dc.subjectRapid eye movementen
dc.subjectLong-termen
dc.subjectEEGen
dc.subjectElectroencephalographyen
dc.subjectNon-rapid eye movementen
dc.titleSeizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: A longitudinal electroencephalography investigationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172327en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:49en
sync.item.modts2025.01.17 15:19:07en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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