Left bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral wall depolarization

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dc.contributor.authorČurila, Karolcs
dc.contributor.authorJurák, Pavelcs
dc.contributor.authorJastrzebski, Marekcs
dc.contributor.authorPrinzen, Fritscs
dc.contributor.authorWaldauf, Petrcs
dc.contributor.authorHalámek, Josefcs
dc.contributor.authorVernooy, Kevincs
dc.contributor.authorSmíšek, Radovancs
dc.contributor.authorKarch, Jakubcs
dc.contributor.authorPlešinger, Filipcs
dc.contributor.authorMoskal, Pawelcs
dc.contributor.authorSušánková, Markétacs
dc.contributor.authorZnojilová, Luciecs
dc.contributor.authorHeckman, Luukcs
dc.contributor.authorViščor, Ivocs
dc.contributor.authorVondra, Vlastimilcs
dc.contributor.authorLeinveber, Pavelcs
dc.contributor.authorOsmančík, Pavelcs
dc.coverage.issue8cs
dc.coverage.volume18cs
dc.date.issued2021-08-11cs
dc.description.abstractBACKGROUND Nonselective His-bundle pacing (nsHBp), nonselective left bundle branch pacing (nsLBBp), and left ventricular septal myocardial pacing (LVSP) are recognized as physiological pacing tech niques. OBJECTIVE The purpose of this study was to compare differences in ventricular depolarization between these techniques using ultrahigh-frequency electrocardiography (UHF-ECG). METHODS In patients with bradycardia, nsHBp, nsLBBp (confirmed concomitant left bundle branch [LBB] and myocardial capture), and LVSP (pacing in left ventricular [LV] septal position without proven LBB capture) were performed. Timings of ventricular activations in precordial leads were displayed using UHF-ECG, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. Duration of local depolarization (Vd) was determined as width of the UHF-QRS complex at 50% of its amplitude. RESULTS In 68 patients, data were collected during nsLBBp (35), LVSP (96), and nsHBp (55). nsLBBp resulted in larger e-DYS than did LVSP and nsH Bp [- 24 ms (-28;-19) vs -12 ms (-16;-9) vs 10 ms (7;14), respectively; P <.001]. nsLBBp produced similar values of Vd in leads V-5 -V-8 (36-43 ms vs 38-43 ms; P = NS in all leads) but longer Vd in leads V-1 -V-4 (47-59 ms vs 41-44 ms; P <.05) as nsH Bp. LVSP caused prolonged Vd in leads V-1 -V-8 compared to nsH Bp and longer Vd in leads V-5 -V-8 compared to nsLBBp (44-51 ms vs 36-43 ms; P <.05) regardless of R-wave peak time in lead V-5 or QRS morphology in lead V-1 present during LVSP. CONCLUSION nslbbp preserves physiological LV depolarization but increases interventricular electrical dyssynchrony. LV lateral wall depolarization during LVSP is prolonged, but interventricular synchrony is preserved.en
dc.formattextcs
dc.format.extent1281-1289cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationHEART RHYTHM. 2021, vol. 18, issue 8, p. 1281-1289.en
dc.identifier.doi10.1016/j.hrthm.2021.04.025cs
dc.identifier.issn1547-5271cs
dc.identifier.orcid0000-0003-0413-3604cs
dc.identifier.orcid0000-0001-7267-4408cs
dc.identifier.other172330cs
dc.identifier.researcheridF-5329-2017cs
dc.identifier.scopus57188873046cs
dc.identifier.urihttp://hdl.handle.net/11012/201482
dc.language.isoencs
dc.publisherELSEVIER SCIENCE INCcs
dc.relation.ispartofHEART RHYTHMcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1547527121004021?via%3Dihubcs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1547-5271/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectDepolarization durationen
dc.subjectDyssynchronyen
dc.subjectHis-bundle pacingen
dc.subjectLeft bundle branch pacingen
dc.subjectLeft ventricular septal myocardial pacingen
dc.subjectUltra-high-frequency electrocardiographyen
dc.titleLeft bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral wall depolarizationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172330en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:39:48en
sync.item.modts2025.01.17 18:48:13en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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