Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

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dc.contributor.authorFolprecht, Martincs
dc.contributor.authorČervinka, Daliborcs
dc.contributor.authorProcházka, Petrcs
dc.coverage.issue23cs
dc.coverage.volume10cs
dc.date.accessioned2021-12-16T11:54:55Z
dc.date.available2021-12-16T11:54:55Z
dc.date.issued2021-11-23cs
dc.description.abstractThis paper is focused on a design of a high-voltage (HV) generator, which is proposed for a high-frequency irreversible electroporation (H-FIRE). The generator produces bursts of bipolar symmetrical pulses. Most HV sources used for cell electroporation are based on a controlled discharge of a capacitor into a resistive load. This solution is very simple, but it is associated with a certain risk of an uncontrolled discharge of the capacitor. We present a different type of the generator, where a DC-AC inverter with pulse transformer is used and where the mentioned risk is eliminated. Our generator is able to deliver bursts with variable length from 50 to 150 s and a gap between bursts can be set from 0.5 to 1.5 s. Pulse frequency can be varied from 65 to 470 kHz and the output voltage is controlled in two ranges from 0 to 1.3 kV or from 0 to 2.5 kV. Results are presented with resistive load and with tissue impedance load.en
dc.formattextcs
dc.format.extent1-17cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationElectronics (MDPI). 2021, vol. 10, issue 23, p. 1-17.en
dc.identifier.doi10.3390/electronics10232898cs
dc.identifier.issn2079-9292cs
dc.identifier.other174971cs
dc.identifier.urihttp://hdl.handle.net/11012/203238
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofElectronics (MDPI)cs
dc.relation.urihttps://www.mdpi.com/2079-9292/10/23/2898cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2079-9292/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectCell electroporationen
dc.subjecttissue ablationen
dc.subjectcapacitor banken
dc.subjectDC-AC inverteren
dc.subjectDC-DC converteren
dc.subjectfrequency generatoren
dc.subjecthigh voltageen
dc.subjectrectangular pulsesen
dc.subjectpulse transformer.en
dc.titleCompact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)en
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-174971en
sync.item.dbtypeVAVen
sync.item.insts2022.01.12 00:59:08en
sync.item.modts2022.01.12 00:16:14en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav výkonové elektrotechniky a elektronikycs
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