Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging
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Date
2023-06-01
Authors
Šuráňová, Markéta
Ďuriš, Miroslav
Štenglová Netíková, Irena
Brábek, Jan
Horák, Tomáš
Jůzová, Veronika
Chmelík, Radim
Veselý, Pavel
0000-0001-8256-1175Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Optica
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Abstract
Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of in vitro enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.
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Citation
Biomedical Optics Express. 2023, vol. 14, issue 6, p. 2689-2708.
https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666
https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666
Document type
Peer-reviewed
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Published version
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en