Feature-overlapper: The tool for DNA analysis overlap

Abstract

This contribution puts focus on a command line tool, which enables detection and analysis of overlapping regions between G-quadruplexes, R-loops and genome annotations for selected genomes. G-quadruplexes and R-loops are structures with high Guanine density, which is an important creation factor for both structures. Common regions (overlap) between both structures can provide us with better possibility to create precise model to detect R-loops and valuable insights when inspecting genome annotations with high R-loop density. The tool was used for multiple research projects and is under constant development bringing new features to the world of bioinformatics.This contribution puts focus on a command line tool, which enables detection and analysis of overlapping regions between G-quadruplexes, R-loops and genome annotations for selected genomes. G-quadruplexes and R-loops are structures with high Guanine density, which is an important creation factor for both structures. Common regions (overlap) between both structures can provide us with better possibility to create precise model to detect R-loops and valuable insights when inspecting genome annotations with high R-loop density. The tool was used for multiple research projects and is under constant development bringing new features to the world of bioinformatics.