Network Analysis Of Proteins Associated With Schizophrenia

Loading...
Thumbnail Image
Date
2018
ORCID
Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract
The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.
Description
Citation
Proceedings of the 24th Conference STUDENT EEICT 2018. s. 273-275. ISBN 978-80-214-5614-3
http://www.feec.vutbr.cz/EEICT/
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
cz
Study field
Comittee
Date of acceptance
Defence
Result of defence
Document licence
© Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
DOI
Citace PRO