The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease
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Roy, Sudeep
Gumulec, Jaromír
Kumar, Akhil
Raudenská, Martina
Baig, Mohd Hassan
Polanská, Hana
Balvan, Jan
Gupta, Mansi
Babula, Petr
Odstrčilík, Jan
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Mark
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Wiley Periodicals
0000-0002-7825-0152 Altmetrics
Abstract
Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.
Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.
Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.
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Brain and Behavior. 2017, vol. 7, issue 9, p. 1-9.
http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract
http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract
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en
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