Variations of flow in human airways as a consequence of lung diseases

Abstract

The efficiency of drug delivery administered by inhalation depends, among other factors, such as size and shape of aerosol particles, significantly also on the flow in the airways. As many lung diseases change both the breathing pattern and the shape of airways, we focus in this study on the influence of several selected diseases on the distribution of flow between the lung lobes and on changes the diseases induce on the course of flowrate. First, we present results of a literature survey focused on the published records of pathological breathing patterns. In the second part, we describe the newly designed breathing simulator and the implementation of the patterns into it. The last part is focused on the experimental verification of fidelity of the simulated breathing patterns.The efficiency of drug delivery administered by inhalation depends, among other factors, such as size and shape of aerosol particles, significantly also on the flow in the airways. As many lung diseases change both the breathing pattern and the shape of airways, we focus in this study on the influence of several selected diseases on the distribution of flow between the lung lobes and on changes the diseases induce on the course of flowrate. First, we present results of a literature survey focused on the published records of pathological breathing patterns. In the second part, we describe the newly designed breathing simulator and the implementation of the patterns into it. The last part is focused on the experimental verification of fidelity of the simulated breathing patterns.