Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system

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dc.contributor.authorKavková, Michaelacs
dc.contributor.authorZikmund, Tomášcs
dc.contributor.authorKala, Annucs
dc.contributor.authorŠalplachta, Jakubcs
dc.contributor.authorLissette Proskauer Pena, Stephaniecs
dc.contributor.authorKaiser, Jozefcs
dc.contributor.authorJežek, Karelcs
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.issued2021-03-16cs
dc.description.abstractAmyloid plaques are small (similar to 50 mu m), highly-dense aggregates of amyloid beta (A beta) protein in brain tissue, supposed to play a key role in pathogenesis of Alzheimer's disease (AD). Plaques' in vivo detection, spatial distribution and quantitative characterization could be an essential marker in diagnostics and evaluation of AD progress. However, current imaging methods in clinics possess substantial limits in sensitivity towards A beta plaques to play a considerable role in AD screening. Contrast enhanced X-ray micro computed tomography (micro CT) is an emerging highly sensitive imaging technique capable of high resolution visualization of rodent brain. In this study we show the absorption based contrast enhanced X-ray micro CT imaging is viable method for detection and 3D analysis of A beta plaques in transgenic rodent models of Alzheimer's disease. Using iodine contrasted brain tissue isolated from the Tg-F344-AD rat model we show the micro CT imaging is capable of precise imaging of A beta plaques, making possible to further analyze various aspects of their 3D spatial distribution and other properties.en
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2021, vol. 11, issue 1, p. 1-10.en
dc.identifier.doi10.1038/s41598-021-84579-xcs
dc.identifier.issn2045-2322cs
dc.identifier.orcid0000-0001-7435-9292cs
dc.identifier.orcid0000-0003-2948-5198cs
dc.identifier.orcid0000-0002-0149-7843cs
dc.identifier.orcid0000-0002-7397-125Xcs
dc.identifier.other172018cs
dc.identifier.researcheridG-9491-2014cs
dc.identifier.researcheridR-1104-2018cs
dc.identifier.researcheridD-6800-2012cs
dc.identifier.scopus7402184758cs
dc.identifier.urihttp://hdl.handle.net/11012/202272
dc.language.isoencs
dc.publisherSpringer Naturecs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttps://www.nature.com/articles/s41598-021-84579-xcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmicro CTen
dc.subjectAlzheimers diseaseen
dc.subjectimagingen
dc.titleContrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT systemen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172018en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:48:17en
sync.item.modts2025.01.17 16:33:40en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Ústav soudního inženýrství. Ústav soudního inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
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