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Item type:Item, Access status: Open Access , Z-DNA Hunter tool for straightforward detection of Z-DNA forming regions and a case study in Drosophila(2025-12-01) Petrovič, Michal; Bartas, Martin; Garratt, Alistair N.; Pečinka, Petr; Dobrovolná, Michaela; Koňaříková, Klára; Trenz, Oldřich; Brázda, Václav; Šťastný, JiříZ-DNA is a left-handed DNA conformation linked to gene regulation, chromatin dynamics, and immunity. Despite its importance, genome-wide prediction of Z-DNA forming sequences (ZFS) remains limited by the absence of fast and accessible tools. Here, we present Z-DNA Hunter, a user-friendly web server for genome-scale ZFS prediction utility. The algorithm employs a pattern-based approach optimized for canonical motifs such as (GC)n and (CA)n repeats, with adjustable parameters for detection stringency. Compared with existing methods, Z-DNA Hunter achieves similar or higher accuracy while reducing runtime from hours to seconds, making large-scale analyses feasible. To demonstrate its application, we analyzed the Drosophila melanogaster genome and uncovered a pronounced enrichment of long ZFS on the X chromosome, contrasting with their near absence on the satellite repeat- and transposable element-rich Y chromosome. These findings illustrate both the scalability of Z-DNA Hunter and its potential to reveal biologically meaningful patterns of non-B-DNA. The tool provides direct visualization and export options (e.g. BedGraph for UCSC Genome Browser) and is freely available at https://bioinformatics.ibp.cz/#/analyse/zdna.Item type:Item, Access status: Open Access , Funkcionální analýza I(VUT v Brně, Fakulta strojního inženýrství, 2026-01-29) Franců, JanUčební text je určen studentům 2. ročníku Fakulty strojního inženýrství VUT v Brně. Obsah: metrické prostory, lineární prostory, Banachovy prostory, Hilbertovy prostory, Lebesgueova míra a integrál, příklady konkrétních prostorů vektorů, posloupností, spojitých a integrovatelných funkcí.Item type:Item, Access status: Open Access , Multisenzorická rezidenční architektura: Přístup zaměřený na člověka v Brně(Vysoké učení technické v Brně. Fakulta architektury) Bala, Tarini; Boetzkes, Servie; Ježková, TerezaThe project idea is inspired by todays need of spaces where someone can move away from their daily routine and find moments of rest and rejuvenation. The proposal explores the relationship between architecture, nature and well-being while creating an environment that encourages reflection, calmness and emotional balance. The design shows how we can inter-relate spatial organization, natural light, ventilation and pleasant views. Also, by providing unrestricted experiences and promote comfort for individuals. The proposal offers the users a short-term stay that supports their mental and emotional well-being by relaxing their mind, body and soul. The design emphasizes creating spaces that support both individual solitude and limited social interaction while allowing users to choose a method to engage with the environment as well as with each other. A strong connection between indoor and outdoor spaces is achieved through open pathways, landscape openness and integrating nature into everyday experience. Overall, the project is designed to create a restorative retreat that responds to the growing need for a space that can nurture human health and emotional resilience through interactions with ones own self and their surroundings.Item type:Item, Access status: Open Access , Adaptivní opětovné využití v ochraně průmyslového dědictví: Případová studie architektonické přestavby(Vysoké učení technické v Brně. Fakulta architektury) Sagmaner, Bengisu; Rozwalka, Szymon; Jakšík, PetrThe diploma thesis “Adaptive Reuse in the Conservation of Industrial Heritage: A Case Study in Architectural Redesign” experiments with the conservation of a post-industrial building in Brno, Trnitá, in the vicinity of Cejl and old industrial zone of the city where the textile industry started during 1750s, and has long been a home to different communities: Jews and Germans before the Second World War, and now to Roma population, now facing a radical shift with renewal projects. Thus, it is in the verge of losing its layered historical, cultural and social identity. The subjected building is the former Brno City Timber Factory located on the Křenová Street, and that is going to be demolished due to the future development projects. The project rather than seeing the building as a static monument or rather than aproaching with object-based preservation method, it aims to see the building as a catalyst to bring the social diversity and nature, and works with the future development of the area. The methodology of the project is formed by the research on the works and readings from Rem Koolhaas, Arno Brandlhuber, architecten De Vylder Vinck Taillieu, Vylder Vinck Taillieu, Yona Friedman, and Richard Sennett.Item type:Item, Access status: Open Access , Ultrasound-Based Assessment of Subcutaneous Adipose Tissue Changes During a 7-Day Ultramarathon: Association with Anthropometric Indices, Not Body Mass(2025-12-01) Chlíbková, Daniela; Knechtle, Beat; Weiss, Katja; Kovacova, Ingrid; Rosemann, ThomasBackground: Accurately tracking body-composition changes in endurance field settings remains methodologically challenging. This study aimed to evaluate whether changes in subcutaneous adipose tissue (SAT) across a 7-day ultramarathon are better reflected by anthropometric indices than by body mass (BM) alone. Methods: Twenty ultrarunners were assessed using both anthropometric indices and ultrasound measurements of SAT thickness, applying a novel method that distinguishes layers including (D-I) versus excluding (D-E) embedded fibrous structures. Measurements were obtained before the race and after Stages 4 and 7. Indices included body mass index (BMI), mass index (MII), and waist-to-height ratio (WHtR). Results: Total SAT thickness decreased significantly for both D-I (p = 0.001) and D-E (p < 0.001). BM, BMI, MII, and WHtR also declined significantly post-race (p < 0.001). SAT reduction was most pronounced at the abdominal and thigh sites. Additionally, ultrarunners with lower D-E values exhibited lower fat at the abdomen and distal triceps. BMI was significantly related to D-E at the upper and lower abdomen and erector spinae; MII was significantly associated with D-E at the upper and lower abdomen; and WHtR correlated with both D-E and D-I at abdominal and erector spinae sites. BM showed no significant association with any SAT parameter. Conclusions: Ultrasound-derived SAT thickness, in combination with BMI, MII, and WHtR, offers a field-feasible approach to evaluate body-composition change during multistage ultramarathons. In contrast, BM alone does not reliably reflect SAT distribution or loss.