ŠPAKOVÁ, A. Probing natural molecules with PPAR- to reveal potent agonist against Cancer [online]. Brno: Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. 2024.
Introduction: Adriana’s thesis, " Probing natural molecules with PPAR- to reveal potent agonist against cancer," aims to search for a natural molecule(s) with potential agonistic properties against Cancer. The aim further extends to understand the connection between the proliferator-activated receptor gamma(PPAR-) and Cancer. The scope of the work includes extensive molecular modelling studies that includes Virtual screening, molecular docking, Simulations and Free binding energy calculations of natural molecules from varied sources. Structure and Organization: The thesis is well-structured, beginning with a comprehensive abstract and introduction that effectively set the stage for the research. Each chapter flows logically from the literature review to the methodology, results, discussion, and conclusion. Content Evaluation: The language is clear and accessible, making complex concepts understandable to non-experts. The literature review is thorough, providing a solid foundation of existing research. The methodology is explained in straightforward terms, making the research approach comprehensible. The results are presented with clear figures and tables, aiding in the understanding of the data. The discussion section effectively interprets the results, linking them back to the research questions and providing insightful analysis. Presentation and Formatting: The thesis is professionally formatted with consistent use of headings and spacing. Visual aids are used effectively to complement the text, and the document is free from significant typographical or grammatical errors. Conclusion and Impact: The conclusions are logical and well-supported, offering practical recommendations for scientific fraternity to validate the reported lead molecules for further validation in the cancer cell-lines. Summary and Final Thoughts: Overall, Adriana’s thesis is a well-written and thoroughly researched document that offers valuable insights into natural molecules solutions for the treatment of Cancer. The work stands out for its clarity, organization, and practical relevance, making it a valuable resource for both academics and practitioners in the field.
Presentation level of the technical report and its scope The thesis is well-presented and broadly covers the scope of the research. The introduction effectively sets the context by discussing the significance of cancer treatment and the role of PPAR-. The objectives are clearly defined and supported with figures and tables appropriately. Formal arrangement of the technical report and its language level The report is structured methodically and adheres to academic standards, with a literature review, methodology, results, and discussion. The language used is precise and technical, suitable for the subject matter. There are minor grammatical errors that can be improved. Student's work with literature The literature review is thorough and demonstrates a deep understanding of the current state of research regarding PPAR- and its role in cancer treatment. This section lays a solid foundation for the experimental work conducted. Professional level, usability of results, or implementation output The professional level of the work is creditable. The methodology is rigorous, utilizing advanced techniques in molecular modeling such as virtual screening, molecular docking, MD simulations, and ADMET analysis. The results are promising, identifying potential natural molecules that could serve as PPAR- agonists with fewer side effects than standard compounds. The practical implications of these findings are significant, suggesting a pathway for the development of new cancer therapies.
eVSKP id 159765