DRAŽKOVÁ, J. Emergentní vlastnosti sítě G1/S [online]. Brno: Vysoké učení technické v Brně. Fakulta strojního inženýrství. 2010.

Posudky

Posudek vedoucího

Palumbo,, Pasquale

Navrhovaná známka

Posudek oponenta

Tomášek, Petr

The thesis deals with the mathematical model of chemical-biological processes which take place in G1-S transition. Chapter 2 describes the cell cycle. Chapter 3 introduces the utilized mathematical background and numerical methods used in the simulations. The model itself is introduced and analyzed in the chapter 4. Finally, chapter 5 gives the main results in the form of simulation outputs and remarkable comments. The thesis contains several formal errors, e.g. : p 10: In Definition 2 should be make good an omission (... the highest derivative of the unknown function appearing in the equation.) p 15: In Definition 25: instead of K*h should be K*h^p, p 39: v_{nuc}[0]=v_{nuc}[0]=0.5 should be v_{nuc}[0]=v_{cyt}[0]=0.5. The help of m-file simula.m is gives the example for time-courses of Cdk1-Cln3_nuc and Ck1-Cln-Far1_nuc - first threshold. The codes of other chemicals are missing in the help. They are just stated in oderko.m. At picture 4.1 should be mentioned the source [2] explicitly. The whole thesis is well logically built and is in the accordance with the goals of the mathematical engineering programme.

Dílčí hodnocení
Kritérium	Známka	Body	Slovní hodnocení
Splnění požadavků a cílů zadání	A
Postup a rozsah řešení, adekvátnost použitých metod	A
Vlastní přínos a originalita	A
Schopnost interpretovat dosaž. vysledky a vyvozovat z nich závěry	A
Využitelnost výsledků v praxi nebo teorii	A
Logické uspořádání práce a formální náležitosti	A
Grafická, stylistická úprava a pravopis	B
Práce s literaturou včetně citací	B

Navrhovaná známka: A

Otázky

Just before the chapter 6 is remarked that k44 should be set carefully, because extreme changes in both directions lead to the enlargement of critical size Ps. There is noticed that k42-k45 are usually set equal at the page 39. Then, is the conclusion that extreme changes of values k44 in both directions lead to enlargement of Ps valid providing that the same changes were applied to k42,k43,k45?

eVSKP id 26472